486-47-5 Usage
Uses
Used in Pharmaceutical Industry:
Ethaverine is used as an antispasmodic agent for its ability to alleviate muscle spasms and related discomfort. Its antispasmodic properties make it a valuable compound in the development of medications for various conditions.
Used in Antimicrobial Applications:
Ethaverine is used as an antimicrobial agent for its potential to combat bacterial infections. Its isoquinoline structure contributes to its effectiveness against certain microorganisms, making it a useful compound in the development of new antibiotics.
Used in Antimalarial Applications:
Ethaverine is used as an antimalarial agent for its potential to treat and prevent malaria, a life-threatening disease caused by Plasmodium parasites. Its ability to target and neutralize these parasites makes it a promising candidate for the development of new antimalarial drugs.
Used in Antiviral Applications:
Ethaverine is used as a cytotoxic antiviral agent for its potential to inhibit the replication and spread of viruses. Its isoquinoline structure allows it to interfere with viral processes, making it a valuable compound in the development of antiviral medications.
Originator
Ethaverine,Shanghai Lansheng
Manufacturing Process
(1) 1 part of 2-(3,4-diethoxy-phenyl)-N-[2-(3,4-diethoxy-phenyl)-2-hydroxyethyl]acetamide (homoveratroyl hydroxyhomo-veratrylamine), prepared from
2-amino-1-(3,4-diethoxy-phenyl)ethanol and (3,4-diethoxy-phenyl)acetyl
chloride, is dissolved in a neutral solvent, such as, for example, chloroform or
benzene. Thereupon, 1 to 3 parts of phosphorus oxychloride are added to the
resulting solution and the no whole is heated for some hours under a reflux
condenser. It should be pointed out here that it is also possible to occur by
allowing the amide solution to flow on to the phosphorus oxychloride with the
application of heat or in the cold. Instead of this, it is also possible to carry
out the reaction in such a way that the reaction mixture is first allowed to
stand in the cold. Then it completed by heating. The base produced in both
cases is obtained by shaking with chloroform after distilling off the solvent and
after alkalization. MP: 145°-147°C.(2) 1 part of 2-(3,4-dimethoxyphenyl)ethylamine is dissolved in 2 parts of
benzene, 1 to 2 parts of phosphorus pentachloride are added thereto and the
whole is heated to boiling. After heating for several hours, the base, which is
formed can be isolated as above described. MP: 147°C.(3) 1 part of N-(3,4-diethoxyphenylacetyl)-β-oxy-β-(3,4-
diethoxyphenyl)ethylamine is dissolved in benzene or chloroform, mixed with
1 to 3 parts by weight of phosphorus oxychloride and boiled under a reflux
condenser for 3 hours whereupon 6,7-diethoxy-1-(3',4'- diethoxybenzyl)isoquinoline base can be isolated in the usual way. MP: 99°-
101°C.
Therapeutic Function
Spasmolytic, Vasodilator, Antiarrhythmic
Check Digit Verification of cas no
The CAS Registry Mumber 486-47-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 6 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 486-47:
(5*4)+(4*8)+(3*6)+(2*4)+(1*7)=85
85 % 10 = 5
So 486-47-5 is a valid CAS Registry Number.
InChI:InChI=1/C24H29NO4.ClH/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20;/h9-12,14-16H,5-8,13H2,1-4H3;1H
