488-47-1

Usage

Chemical Properties

grey granular product

Uses

Tetrabromocatechol is used as a pharmaceutical intermediate.

InChI:InChI=1/C6H2Br4O2/c7-1-2(8)4(10)6(12)5(11)3(1)9/h11-12H

Upstream product

• 6665-98-1 3-nitrobenzene-1,2-diol 
• 99-50-3 3,4-Dihydroxybenzoic acid 
• 3316-09-4 1,2-dihydroxy-4-nitrobenzene 
• 303-38-8 2,3-Dihydroxybenzoic acid 
• 61203-46-1 3-bromo-4,5-dihydroxybenzoic acid 
• 15930-53-7 6-bromo-3,4-methylenedioxybenzaldehyde 
• 67-66-3 chloroform 
• 120-80-9 benzene-1,2-diol 
• 7726-95-6 bromine 
• 60-29-7 diethyl ether 
• 7664-93-9 sulfuric acid 
• 64-19-7 acetic acid 
• 2435-54-3 o-bromanil 
• 16414-34-9 3-bromo-4,5-dihydroxybenzaldehyde 

Downstream Products

• 26884-57-1 3,4,5,6-Tetrabromo-1,2-dimethoxybenzene 
• 103963-58-2 3,4,5,6-<2H4>-1,2-dihydroxybenzene 
• 2435-54-3 o-bromanil 
• 857417-29-9 3,4,6-tribromocatechol 

Relevant academic research and scientific papers

Reaction of 1,1-Bis(Diphenylphosphino)Methane with O-Quinones and Naphtho[2,1-B]Furan-1,2-Dione. Novel Synthesis of Bis(Diphenylphosphoryl) Derivatives and their Antimicrobial Activity

The reaction of 1,1-bis(diphenylphosphino)methane with substituted o-quinones afforded the novel 6-[bis(diphenylphosphoryl)methyl]-and 6-bis(diphenyl phosphoryl)methylidene derivatives. Moreover, 1,1-bis(diphenylphosphino)methane reacts with 3,4,5,6-tetrabromo-o-benzoquinone to give only the new 6-[bis(diphenylphosphoryl)methyl] derivative. Mechanisms accounting for the formation of the new products are discussed. The antimicrobial activity of some of the newly synthesized compounds was also examined.

On the redox reaction of 1,2-bis(diphenylphosphino) alkanes toward o -, and p-quinones

The reaction of 1,2-bis(diphenylphosphino)ethane with substituted o-benzo-quinones afforded new bis(6-hydroxycyclohexa-2,4-dienone) derivatives. Treatment of the same reagent with o-naphthoquinone, phenanthrenequinone, and acenaphthenequinone gave the res

An efficient strategy for protecting dihydroxyl groups of catechols

A novel strategy for protecting dihydroxyl groups of catechols has been developed. Base-mediated cyclizations of catechols with 1,3-dibromopropane provided the corresponding benzo[b]1,4-dioxepans, and herefrom the protecting group was easily cleaved by aluminum chloride. The preparation of the antibacterial and antifungal agent 4-(2-aminothiazol-4-yl)benzene-1,2-diol from catechol reliably verified its availability amenable to various harsh reaction conditions. Georg Thieme Verlag Stuttgart - New York.

In-vitro cytotoxic activities of the major bromophenols of the red alga Polysiphonia lanosa and some novel synthetic isomers

Bioassay-guided fractionation was applied to the cytotoxic chloroform fraction of the red alga Polysiphonia lanosa. The major compounds of the most active fraction were identified using GLC-MS analysis as lanosol (1), methyl, ethyl, and n-propyl ethers of lanosol (1a, 1b, and 1c, respectively), and aldehyde of lanosol (2), although 1b appears to be an artifact arising during the fractionation procedure. These compounds and other known bromophenols were synthesized in addition to four novel isomers (3, 3a-c). The cytotoxic activities of all the synthetic compounds were determined against DLD-1 cells using the MTT assay. Compounds with IC50 50 = 1.72 and 0.80 μmol, respectively), and its effect on the cell cycle was studied using flow cytometry.

Chemistry of L-ascorbic acid. Part 3.1 Photoreduction of quinones with 5,6-O-isopropylidene-L-ascorbic acid

Upon irradiation with UV light, instead of undergoing the Paterno-Buechi reaction, 5,6-O-isopropyIidene-L-ascorbic acid reduced quinones quite efficiently and rapidly to the corresponding hydroquinones. The Royal Society of Chemistry 2000.