488-47-1

Basic information

• Product Name: TETRABROMOCATECHOL
• Synonyms: TETRABROMOPYROCATECHOL;TETRABROMOCATECHOL;3,4,5,6-tetrabromo-2-benzenediol;3,4,5,6-tetrabromocatechol;tetrabromo-pyrocatecho;3,4,5,6-tetrabromo-1,2-benzenediol;3,4,5,6-Tetrabromobenzene-1,2-diol;Tetrabromobenzene-1,2-diol
• CAS NO: 488-47-1
• Molecular Formula: C₆H₂Br₄O₂
• Molecular Weight: 425.69
• EINECS: 207-678-9
• Mol File: 488-47-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 189-193 °C(lit.)
• Boiling Point: 339.3 °C at 760 mmHg
• Flash Point: 159 °C
• Appearance: /
• Density: 2.6533 (rough estimate)
• Vapor Pressure: 4.73E-05mmHg at 25°C
• Refractive Index: 1.5000 (estimate)
• PKA: 5.50±0.33(Predicted)
• Water Solubility: It is partly miscible with water.
• BRN: 2051548
• CAS DataBase Reference: TETRABROMOCATECHOL(CAS DataBase Reference)
• NIST Chemistry Reference: TETRABROMOCATECHOL(488-47-1)
• EPA Substance Registry System: TETRABROMOCATECHOL(488-47-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• RTECS: UX2430000
• Hazardous Substances Data: 488-47-1(Hazardous Substances Data)

Usage

Chemical Properties

grey granular product

Uses

Tetrabromocatechol is used as a pharmaceutical intermediate.

InChI:InChI=1/C6H2Br4O2/c7-1-2(8)4(10)6(12)5(11)3(1)9/h11-12H

Upstream product

• 6665-98-1 3-nitrobenzene-1,2-diol 
• 3316-09-4 1,2-dihydroxy-4-nitrobenzene 
• 111167-61-4 3,5-dibromocatechol 
• 7726-95-6 bromine 
• 120-80-9 benzene-1,2-diol 
• 64-19-7 acetic acid 
• 99-50-3 3,4-Dihydroxybenzoic acid 
• 67-66-3 chloroform 
• 583-63-1 ortoquinone 
• 303-38-8 2,3-Dihydroxybenzoic acid 
• 7446-70-0 aluminium trichloride 
• 2435-54-3 o-bromanil 
• 71-43-2 benzene 
• 2071-20-7 bis-diphenylphosphinomethane 

Downstream Products

• 26884-57-1 3,4,5,6-Tetrabromo-1,2-dimethoxybenzene 
• 103963-58-2 3,4,5,6-<2H4>-1,2-dihydroxybenzene 
• 857417-29-9 3,4,6-tribromocatechol 
• 57155-88-1 C₆Br₄O₂^(2-)*Sn⁽²⁺⁾ 
• 1374792-63-8 1,2,3,4-tetrabromo-5,6-bis(hexyloxy)benzene 
• 931-17-9 1,2-Cyclohexanediol 
• 108-94-1 cyclohexanone 
• 533-60-8 cyclohexanone-2-ol 
• 108-93-0 cyclohexanol 
• 108-95-2 phenol 

Relevant articles and documents

Reaction of 1,1-Bis(Diphenylphosphino)Methane with O-Quinones and Naphtho[2,1-B]Furan-1,2-Dione. Novel Synthesis of Bis(Diphenylphosphoryl) Derivatives and their Antimicrobial Activity

The reaction of 1,1-bis(diphenylphosphino)methane with substituted o-quinones afforded the novel 6-[bis(diphenylphosphoryl)methyl]-and 6-bis(diphenyl phosphoryl)methylidene derivatives. Moreover, 1,1-bis(diphenylphosphino)methane reacts with 3,4,5,6-tetrabromo-o-benzoquinone to give only the new 6-[bis(diphenylphosphoryl)methyl] derivative. Mechanisms accounting for the formation of the new products are discussed. The antimicrobial activity of some of the newly synthesized compounds was also examined.

An efficient strategy for protecting dihydroxyl groups of catechols

A novel strategy for protecting dihydroxyl groups of catechols has been developed. Base-mediated cyclizations of catechols with 1,3-dibromopropane provided the corresponding benzo[b]1,4-dioxepans, and herefrom the protecting group was easily cleaved by aluminum chloride. The preparation of the antibacterial and antifungal agent 4-(2-aminothiazol-4-yl)benzene-1,2-diol from catechol reliably verified its availability amenable to various harsh reaction conditions. Georg Thieme Verlag Stuttgart - New York.

Chemistry of L-ascorbic acid. Part 3.1 Photoreduction of quinones with 5,6-O-isopropylidene-L-ascorbic acid

Upon irradiation with UV light, instead of undergoing the Paterno-Buechi reaction, 5,6-O-isopropyIidene-L-ascorbic acid reduced quinones quite efficiently and rapidly to the corresponding hydroquinones. The Royal Society of Chemistry 2000.