4252-31-7

Basic information

• Product Name: Benzamide, N-formyl- (7CI,8CI,9CI)
• Synonyms: Benzamide, N-formyl- (7CI,8CI,9CI);N-formylbenzamide;Formylbenzoylamine;N-Benzoylformamide;N-methanoylbenzamide
• CAS NO: 4252-31-7
• Molecular Formula: C₈H₇NO₂
• Molecular Weight: 149.14668
• Product Categories: AMIDE
• Mol File: 4252-31-7.mol
• Article Data: 43

Chemical Properties

• Melting Point: 112-113 °C(Solv: ligroine (8032-32-4))
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.173g/cm³
• Refractive Index: 1.543
• PKA: 10.97±0.46(Predicted)
• CAS DataBase Reference: Benzamide, N-formyl- (7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-formyl- (7CI,8CI,9CI)(4252-31-7)
• EPA Substance Registry System: Benzamide, N-formyl- (7CI,8CI,9CI)(4252-31-7)

Safety Data

• Hazardous Substances Data: 4252-31-7(Hazardous Substances Data)

Usage

General Description

Benzamide, N-formyl- is a chemical compound with the molecular formula C8H7NO2. It belongs to the class of benzamides and is characterized by the presence of a formyl group attached to the nitrogen atom of the benzene ring. Benzamide, N-formyl- is a white to off-white solid with a melting point of around 195-197 degrees Celsius. It is commonly used as a building block in organic synthesis and as a starting material for the preparation of various pharmaceuticals and agrochemicals. The compound has also shown potential biological activity, with some studies suggesting antitumor and antimicrobial properties.

InChI:InChI=1/C8H7NO2/c10-6-9-8(11)7-4-2-1-3-5-7/h1-6H,(H,9,10,11)

Upstream product

• 495-69-2 Hippuric Acid 
• 20662-89-9 4-phenyl-1,3-oxazole 
• 55-21-0 benzamide 
• 134965-38-1 Hex-1-en-2-yl formate 
• 72773-04-7 N-formylbenzotriazole 
• 2258-42-6 formyl acetic anhydride 
• 102254-70-6 4-dimethylamino-2-phenyl-1-thia-3-aza-buta-1,3-diene 
• 393-52-2 2-Fluorobenzoyl chloride 
• 13345-09-0 6-phenyluracil 
• 6282-02-6 N-(hydroxymethyl)benzamide 
• 121876-96-8 4-Dimethylamino-2-phenyl-1-oxa-3-azabuta-1,3-diene 
• 98-88-4 benzoyl chloride 
• 644-33-7 N,N'-ethanediyl-bis-benzamide 
• 75-05-8 acetonitrile 

Downstream Products

• 869902-41-0 (Z)-3-benzoylamino-acrylic acid ethyl ester 
• 51-17-2 benzoimidazole 
• 614-97-1 6-methyl-1H-benzo[d]imidazole 
• 4887-83-6 7-methyl-1H-benzo[d]imidazole 
• 4887-80-3 6-methoxy-1H-benzo[d]imidazole 
• 1977-72-6 6-fluoro-1H-benzo[d]imidazole 
• 4887-82-5 6-chloro-benzoimidazole 
• 4887-88-1 6-bromo-1H-benzo[d]imidazole 
• 94-52-0 6-nitro-1H-benzo[d]imidazole 
• 6287-83-8 1H-benzo[d]imidazole-6-carbonitrile 
• 26663-77-4 methyl 1H-benzo[d]imidazole-6-carboxylate 
• 582-60-5 5,6-dimethyl-1H-benzo[d]imida-zole 
• 269-07-8 naphtho[2,3-d]imidazole 
• 1632-83-3 1-Methylbenzimidazole 

Relevant articles and documents

Irreversible Inhibition of Mammalian and Insect Peptidylglycine &α-Hydroxylating Monooxygenases (PHMs), Peptide Amidating Enzymes, by N-Formyl Amides

A series of N-formyl amides were synthesized by condensation of N,N-bis(trimethylsilyl)formamide with acid chlorides (59-90percent yields), or by reaction of hydroxyglycyl peptides with 90percent hydrogen peroxide (45percent yield); a number of N-formyl amides which bear a phenyl substituent are mechanism-based irreversible inactivators of peptidylglycine α-hydroxylating monooxygenases purified from pig pituitary and from honeybee heads.

Epoxidation of Vinylamides by Dimethyldioxirane: First Spectral Evidence for Enamide Oxides

The oxidation of the (E)- and (Z)-N-propenylbenzamides (1) by dimethyldioxirane (DMD) in acetone solution leads to the α-amido epoxides 2, which were detected by low-temperature NMR spectroscopy; above -50 deg C they dimerize to the diastereomeric dioxane

Immobilized Zn(OAc)2on bipyridine-based periodic mesoporous organosilica for N -formylation of amines with CO2and hydrosilanes

Zinc acetate (Zn(OAc)2) was successfully immobilized on a bipyridine-based periodic mesoporous organosilica (BPy-PMO-TMS), as confirmed by solid-state NMR and energy-dispersive X-ray spectroscopies, X-ray diffractometry, and nitrogen adsorption/desorption isotherm analyses. The immobilized Zn complex, Zn(OAc)2(BPy-PMO-TMS), exhibited good catalytic activity during the N-formylations of amines and amides with CO2 and PhSiH3 to produce the corresponding formamides. Zn(OAc)2(BPy-PMO-TMS) with a lower Zn loading was found to exhibit higher catalytic activity.

Designing a Cr-catalyst bearing redox non-innocent phenalenyl-based ligand towards hydrosilylative CO2functionalization

Herein, we report the synthesis of a Cr(iii)-complex bearing a redox non-innocent phenalenyl-based ligand and its use as a catalyst for SET mediated hydrosilylative reduction of carbon dioxide towards formylation of primary amides under mild conditions. A