26055-07-2

Upstream product

• 2448-45-5 Cbz-D-Phe 
• 2592-95-2 benzotriazol-1-ol 
• 1161-13-3 N-Cbz-L-Phe 
• 137283-64-8 Carbonic acid benzotriazol-1-yl ester isopropenyl ester 
• 54769-22-1 1-methanesulfonyloxy-1,2,3-benzotriazole 
• 89028-37-5 1,1-dibenzotriazolo oxallate(DBTO) 

Downstream Products

• 80262-29-9 Z-Phe-Leu-Arg(Mds)-Arg(Mds)-Ile-Arg(Mds)-Pro-OBut 
• 184105-34-8 (3S,4S)-3-(2S-2-benzyloxycarbonylamino-2-phenylmethyl-acetamido)-4-acetoxy-azetidin-2-one 
• 75539-79-6 benzyloxycarbonyl-D-Phe-Phe-Gly 
• 4892-10-8 N-(benzyloxycarbonyl)-L-phenylalanyl-L-phenylalanine methyl ester 
• 2778-34-9 ethyl [(2S)-2-(benzyloxycarbonylamino)-3-phenylpropanoylamino]acetate 

Relevant academic research and scientific papers

Design and synthesis of 6-substituted amino-4-oxa-1-azabicyclo[3,2,0]heptan-7-one derivatives as cysteine proteases inhibitors

A series of 6-substituted amino-4-oxa-1-azabicyclo[3,2,0]heptan-7-one compounds was designed and synthesized as a new class of inhibitors for cysteine proteases cathepsins B, L, K, and S. One compound (5S,6S)-6-(N-benzyloxycarbonyl-L-phenylalanyl) amino-4

An improved method for the synthesis of active esters of N-protected amino acids and subsequent synthesis of dipeptides

4-Dimethylaminopyridine-catalyzed reaction of mixed carbonates 3 with N-protected amino acids 4 gave the corresponding active esters 5-9, from which dipeptides 11-18 were synthesized by aminolysis with amino acids 10.

A New Method for the Preparation of Active Esters Using Di-2-pyridyl Carbonate

The use of di-2-pyridyl carbonate in the presence of a catalytic amount of 4-dimethylaminopyridine is found to be very effective in the preparation of various active esters.

A Convenient Synthesis of Peptide Using Oxallates

The equimolar reactions of N-protected amino acids , amino acids or amino acid esters with oxallates (1a-1e) having active ester groups in the presence of pyridine in acetonitrile afforded the corresponding dipeptides via active esters in good yields.

Sulfonic acid esters

A novel process for the amidation or esterification which comprises reacting a compound having a carboxy group with a compound having an amino or imino group which can be acylated or with a compound having a hydroxy group in the presence of a sulfonic acid ester of the formula: wherein R1 is an organic group and R2 O-- is a residue of a strongly acidic N-hydroxy compound as a condensation agent, and a novel sulfonic acid ester useful as such a condensation agent and a process for the preparation thereof.