4900-66-7

Basic information

• Product Name: 2-methoxy-1-nitronaphthalene
• Synonyms: 1-Nitro-2-methoxynaphthalene;Methyl 1-nitronaphth-2-yl ether
• CAS NO: 4900-66-7
• Molecular Formula: C₁₁H₉NO₃
• Molecular Weight: 203.1941
• EINECS: 225-529-6
• Mol File: 4900-66-7.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 357.7°Cat760mmHg
• Flash Point: 172.1°C
• Appearance: /
• Density: 1.274g/cm³
• Vapor Pressure: 5.53E-05mmHg at 25°C
• Refractive Index: 1.638
• CAS DataBase Reference: 2-methoxy-1-nitronaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxy-1-nitronaphthalene(4900-66-7)
• EPA Substance Registry System: 2-methoxy-1-nitronaphthalene(4900-66-7)

Safety Data

• Hazardous Substances Data: 4900-66-7(Hazardous Substances Data)

Usage

General Description

2-methoxy-1-nitronaphthalene, also known as 2-methoxynitronaphthalene, is a chemical compound with the molecular formula C11H9NO3. It is a derivative of naphthalene with a methoxy group and a nitro group attached to the aromatic ring. 2-methoxy-1-nitronaphthalene is commonly used as a precursor in the synthesis of various organic compounds and pharmaceutical products. It is a pale yellow solid with a high melting point and is known to be mildly toxic if ingested or inhaled. 2-methoxy-1-nitronaphthalene also has the potential to be harmful to the environment if released into water or soil. Overall, this chemical compound has important applications in the field of organic chemistry and pharmaceutical synthesis, but it should be handled with care due to its toxic and environmental impact.

InChI:InChI=1/C11H9NO3/c1-15-10-7-6-8-4-2-3-5-9(8)11(10)12(13)14/h2-7H,1H3

Upstream product

• 93-04-9 2-Methoxynaphthalene 
• 323-09-1 2-fluoronaphthalene 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 
• 5392-12-1 2-methoxy-1-naphthaldehyde 
• 56-23-5 tetrachloromethane 
• 77-78-1 dimethyl sulfate 
• 88-75-5 2-hydroxynitrobenzene 
• 550-60-7 1-nitro-2-naphthol 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 342-64-3 2-fluoro-1-nitro-naphthalene 

Downstream Products

• 57404-87-2 3-methoxy-1-methylnaphthalene 
• 550-60-7 1-nitro-2-naphthol 
• 123856-15-5 5-nitro-6-methoxy-2-bromonaphthalene 
• 4920-80-3 3-methoxy-2-nitrobenzoic acid 
• 98589-66-3 4-methoxy-3-nitro-phthalic acid 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 1547162-41-3 5-hydroxypomalidomide 
• 1572936-74-3 2-(2-methoxynaphthalen-1-ylamino)-5-nitrobenzoic acid 
• 2246-42-6 2-methoxynaphthylamine 
• 69745-41-1 1-Nitro-2-methoxy-4-(2-phenylethyl)-naphthalen 
• 103369-02-4 2-(3-methoxy-4-nitronaphthyl)-1-phenylethanol 
• 26207-06-7 4-methylnaphthalen-2-ol 
• 606-57-5 1-nitro-2-naphthylamine 
• 69745-38-6 1-Nitro-2-methoxy-4-(2-phenylethyl)-3,4-dihydronaphthalen 

Relevant articles and documents

ION CHANNEL ANTAGONISTS/BLOCKERS AND USES THEREOF

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Iodine(III)-Catalyzed Electrophilic Nitration of Phenols via Non-Br?nsted Acidic NO2+ Generation

The first catalytic procedure for the electrophilic nitration of phenols was developed using iodosylbenzene as an organocatalyst based on iodine(III) and aluminum nitrate as a nitro group source. This atom-economic protocol occurs under mild, non-Br?nsted acidic and open-flask reaction conditions with a broad functional-group tolerance including several heterocycles. Density functional theory (DFT) calculations at the (SMD:MeCN)Mo8-HX/(LANLo8+f,6-311+G) level indicated that the reaction proceeds through a cationic pathway that efficiently generates the NO2+ ion, which is the nitrating species under neutral conditions.

Direct nitration method of electron-enriched aromatic hydrocarbons

The invention discloses a direct nitration method of electron-enriched aromatic hydrocarbons, and belongs to the field of organic synthesis. The direct nitration method is a novel green free radical nitration method; aromatic hydrocarbons are taken as raw materials, acetonitrile, dichloromethane, chloroform, or acetone is taken as a reaction solvent, at room temperature conditions, the raw materials and green nitration reagent tert-butyl nitrite (TBN) are subjected to free radical nitration so as to obtain nitro-aromatic compounds. According to the direct nitration method, no metal is adoptedin reaction, tert-butyl nitrite is directly adopted in nitration reaction. Electron-donating groups such as OMe are introduced, the electron density of aromatic compounds is increased, the nitration reaction possibility is increased. The using amount of tert-butyl nitrite is reduced; only a product and tert-butyl alcohol are generated, environment pollution is reduced. The direct nitration methodis promising in application prospect in the field of nitro-aromatic compound synthesis, green nitration is realized, and a novel idea is provided for large-scale industrialized nitro-aromatic compoundproduction.