323-09-1

Basic information

• Product Name: 2-FLUORONAPHTHALENE
• Synonyms: 2-Fluoronaphthalene ,98%;b-Fluoronaphthalene;2-fluoronaphthalene radical-cation;2-Fluoronapthelene;2-Fluoronaphth;Naphthalene, 2-fluoro-;2-FLUOROPHTHALENE;2-FLUORONAPHTHALENE
• CAS NO: 323-09-1
• Molecular Formula: C₁₀H₇F
• Molecular Weight: 146.16
• EINECS: 206-299-6
• Product Categories: Alpha Sort;E-LAlphabetic;F;FA - FLChemical Class;Naphthalenes;Volatiles/ Semivolatiles;Naphthalene derivatives;600 Series Wastewater Methods;Chemical Class;FluoroEPA;Halogenated;Method 625;FluoroAnalytical Standards
• Mol File: 323-09-1.mol
• Article Data: 36

Chemical Properties

• Melting Point: 61°C
• Boiling Point: 59.09°C (rough estimate)
• Flash Point: 65 °C
• Appearance: /
• Density: 1.1474 (rough estimate)
• Refractive Index: 1.5939 (estimate)
• Storage Temp.: room temp
• CAS DataBase Reference: 2-FLUORONAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORONAPHTHALENE(323-09-1)
• EPA Substance Registry System: 2-FLUORONAPHTHALENE(323-09-1)

Safety Data

• Hazard Codes: T,Xn
• Statements: 45-23/24/25-36/37/38-43-63-36-22-40
• Safety Statements: 53-23-24/25-36/37
• RIDADR: UN 1593 6.1/PG 3
• Hazardous Substances Data: 323-09-1(Hazardous Substances Data)

Usage

Chemical Properties

White crystal

Uses

2-Fluoronapthelene is a naphthalene which shows inhibition towards cytochrom P450 2A6 and 2A5.

InChI:InChI=1/C10H7F/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-7H

Upstream product

• 20893-80-5 naphthalene-2-diazonium chloride 
• 450-58-8 2-naphthyldiazonium tetrafluoroborate 
• 91-59-8 naphthalen-2-ylamine 
• 75-43-4 Dichlorofluoromethane 
• 865-47-4 potassium tert-butylate 
• 95-13-6 1-indene 
• 91-20-3 naphthalene 
• 396-26-9 2-fluoronaphthalene - picric acid complex 
• 3076-57-1 2-naphthyllead triacetate 
• 575-08-6 6-fluoro-1-naphthalenecarboxylic acid 
• 75-89-8 2,2,2-trifluoroethanol 
• 67-56-1 methanol 
• 612-55-5 2-iodonaphthalene 
• 15300-41-1 (naphthalen-2-yl)dimethylcarbamate 

Downstream Products

• 62062-39-9 1-naphthalen-1-yl-piperidine 
• 5465-85-0 N-(2-naphthyl)piperidine 
• 108981-94-8 2-phenyl-1-naphthalenecarboxylic acid 
• 2178-02-1 3-phenyl-2-naphthioc acid 
• 85679-03-4 1-phenylnaphthalene-2-carboxylic acid 
• 1523-11-1 naphthalen-2-yl acetate 
• 82128-59-4 7-fluoro-1-naphthaldehyde 
• 25016-01-7 5-bromo-2-methoxybenzaldehyde 
• 82128-49-2 2-fluoro-1-naphthaldehyde 
• 21597-61-5 2-fluoro-3-naphthaldehyde 
• 85328-29-6 α,α-diphenyl-2-naphthalene methanol 
• 612-78-2 2,2'-binaphthalene 
• 91-20-3 naphthalene 
• 93-22-1 2-pentylnaphthalene 

Relevant articles and documents

A simple route to 6- and 7-fluoro-substituted naphthalene-1-carboxylic acids

A simple one-pot method for the synthesis of 6-fluoro- and 6,7-difluoro-1-naphthoic acid is described. 6-Fluoro-1-naphthoic acid can be converted into 7-fluoro-1-naphthoic acid in three straightforward steps.

Method for pipeline continuous fluorination with fluorine salt as fluorine source

The method comprises the following steps: dissolving a fluorine salt in an aqueous polar aprotic solvent as reaction liquid A, dissolving an aryl (heterocyclic) chloride in a polar aprotic solvent as reaction liquid B, and reacting a polar aprotic solvent in the reaction liquid A with a polar aprotic solvent of the reaction liquid B. The reaction medium consisting of the preheated reaction liquid A and the preheated reaction liquid B enters the reaction coil for a fluorination reaction, and the resulting product from the reaction coil is subjected to post-treatment to obtain the product. The method has the characteristics of no need of adding a phase transfer catalyst, continuous production, low production cost and the like.

Hypervalent Iodine(III)-Catalyzed Balz–Schiemann Fluorination under Mild Conditions

An unprecedented hypervalent iodine(III) catalyzed Balz–Schiemann reaction is described. In the presence of a hypervalent iodine compound, the fluorination reaction proceeds under mild conditions (25–60 °C), and features a wide substrate scope and good functional-group compatibility.

Ni-Catalyzed Stannylation of Aryl Esters via C?O Bond Cleavage

A Ni-catalyzed stannylation of aryl esters with air- and moisture-insensitive silylstannyl reagents via Csp2 ?O cleavage is described. This protocol is characterized by its wide scope, including challenging combinations, thus enabling access to versatile building blocks and orthogonal C?heteroatom bond formations.