4903-95-1

Basic information

• Product Name: 2-PYRIDIN-2-YL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER
• Synonyms: 2-PYRIDIN-2-YL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER;CYCLOPROPANECARBOXYLIC ACID, 2-(2-PYRIDINYL)-, ETHYL ESTER;2-(2-Pyridinyl)cyclopropanecarboxylic acid ethyl ester
• CAS NO: 4903-95-1
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Mol File: 4903-95-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 287.938°C at 760 mmHg
• Flash Point: 127.941°C
• Appearance: /
• Density: 1.161g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: 2-PYRIDIN-2-YL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PYRIDIN-2-YL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER(4903-95-1)
• EPA Substance Registry System: 2-PYRIDIN-2-YL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER(4903-95-1)

Safety Data

• Hazardous Substances Data: 4903-95-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H13NO2/c1-2-14-11(13)9-7-8(9)10-5-3-4-6-12-10/h3-6,8-9H,2,7H2,1H3

Upstream product

• 100-69-6 2-vinylpyridine 
• 623-73-4 diazoacetic acid ethyl ester 
• 1121-60-4 pyridine-2-carbaldehyde 
• 140-88-5 ethyl acrylate 
• 274-59-9 triazolopyridine 
• 91496-20-7 ethyl 2-(phenylsulfanyl)cyclopropane-1-carboxylate 
• 109-04-6 2-bromo-pyridine 
• 1774-47-6 trimethylsulfoxonium iodide 
• 7340-23-0 ethyl 3-(pyridin-2-yl)acrylate 
• 186581-53-3 diazomethane 

Downstream Products

• 90563-75-0 (+/-)-cis-2-[2]pyridyl-cyclopropanecarboxylic acid 
• 90563-75-0 (±)-trans-2-(pyridin-2-yl)cyclopropanecarboxylic acid 

Relevant articles and documents

Reactivity of [1,2,3]Triazolo[1,5-a]pyridines as 1,3-dipoles

We have studied the reactions between [1,2,3]Triazolo[1,5-a]pyridines 1a,b,c and electron-deficient ethylenes in different conditions. Compounds 1a and 1b react with ethyl propiolate, and dimethyl acetylene dicarboxylate giving a new class of biaryl compounds pyridyl pyrazoles, and with ethyl acrylate giving pyridyl cyclopropanes. Compound 1c did not give any product in the studied conditions. A proposal of mechanism of these reactions is done in which the triazolopyridines act as 1,3-dipoles giving 1,3-dipolar cycloadditions.

Cobalt(II)-based Metalloradical Activation of 2-(Diazomethyl)pyridines for Radical Transannulation and Cyclopropanation

A new catalytic method for the denitrogenative transannulation/cyclopropanation of in-situ-generated 2-(diazomethyl)pyridines is described using a cobalt-catalyzed radical-activation mechanism. The method takes advantage of the inherent properties of a CoIII-carbene radical intermediate and is the first report of denitrogenative transannulation/cyclopropanation by a radical-activation mechanism, which is supported by various control experiments. The synthetic benefits of the metalloradical approach are showcased with a short total synthesis of (±)-monomorine.

CAFFEINE INHIBITORS OF MTHFD2 AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.