491-58-7

Usage

Uses

Used in Pharmaceutical Industry:
Chrysarobin crude from Goa powder is used as a therapeutic agent for the treatment of skin conditions such as psoriasis and eczema. It functions by inhibiting the rapid growth of skin cells, reducing inflammation, and suppressing the immune response that contributes to these conditions.
Used in Cosmetic Industry:
Due to its anti-inflammatory and antifungal properties, Chrysarobin crude from Goa powder is also used in cosmetic formulations to address skin irritations and promote skin health.
It is crucial to use Chrysarobin crude from Goa powder under the guidance of a healthcare professional to minimize the risk of skin irritation and other potential side effects.

InChI:InChI=1/C15H12O3/c1-8-5-10-7-9-3-2-4-11(16)13(9)15(18)14(10)12(17)6-8/h2-6,16-17H,7H2,1H3

Upstream product

• 481-74-3 Chrysophanol 
• 476-56-2 islandicin 
• 6247-99-0 1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone 
• 491-60-1 emodinanthrone 
• 481-72-1 1,8-dihydroxy-3-hydroxymethyl-9,10-anthracenedione 
• 10034-85-2 hydrogen iodide 
• 64-19-7 acetic acid 
• 7647-01-0 hydrogenchloride 
• 17062-54-3 chrysophanol-10,10′-bianthrone 

Downstream Products

• 481-74-3 Chrysophanol 
• 61446-06-8 1,8,9-triacetoxy-3-methyl-anthracene 
• 491-59-8 1,8,9-trihydroxy-3-methyl-anthracene 
• 18713-45-6 1,8-diacetoxy-3-methyl-anthraquinone 

Relevant academic research and scientific papers

Cytotoxicity of rhamnosylanthraquinones and rhamnosylanthrones from Rhamnus nepalensis

An extract of the fruits of Rhamnus nepalensis collected in Hoa Binh Province, Vietnam, was cytotoxic to KB cells. A bioassay-guided fractionation led to the isolation of a series of known anthraquinones and anthrones, one new rhamnosylanthraquinone, 3′-O-acetylfrangulin A (8), several new rhamnosylanthrones, the prinoidin-emodin bianthrones (9A-D), the prinoidin bianthrones (10A,B), and the rhamnepalins (11A-C). A structure-cytotoxic activity relationship study was performed on these isolates and some semisynthetic derivatives.

CONVERSION OF EMODIN TO CHRYSOPHANOL IN A CELL-FREE SYSTEM FROM PYRENOCHAETA TERRESTRIS

Incubation of a cell-free extract from Pyrenochaeta terrestris with emodin gave a single major product which was purified and identified as chrysophanol by mass spectrometry.Maximum conversion of emodin to chrysophanol was obtained with anaerobic conditions and NADPH, ATP, mercaptoethanol, iron(II) and glycerol.The apparent Km for emodin in the crude extract was 1.0 +/- 0.2 μM.At 4.2 μM, the conversion of emodin was 17 times the conversion of emodinanthrone to chrysophanol plus chrysophanolanthrone.It is proposed that chrysophanol is synthesized in plant and fungal species primarily by dehydroxylation of emodin.Key Word Index-Pyrenochaeta terrestris; Sphaeropsidaceae; cell-free system; biosynthesis; emodin; chrysophanol