956077-87-5Relevant academic research and scientific papers
Novel approach in the synthesis of imidazo [1, 2-a] pyridine from phenyl acrylic acids
Mutkule, Nilesh,Bugad, Nageshprasad,Mokale, Santosh,Choudhari, Vilas,Ubale, Milind
, p. 3186 - 3192 (2020/06/23)
This paper describes highly efficient concise method for the synthesis of imidazo[1,2-a] pyridine. It is a first report employing, amino pyridines, copper nitrate, and phenyl acrylic acids in the synthesis of imidazo[1,2-a] pyridine. The silent features of the devised protocol include the high yield, milder reaction conditions, and shorter reaction time.
NIS-promoted multicomponent reaction of 2-aminopyridines with aldehydes and nitromethane for the synthesis of 3-nitroimidazo[1.2-a]pyridines
Sun, Jinwei,Yang, Xinrui,Liu, Yun,Wang, Yi,Pan, Yi
, p. 1449 - 1455 (2020/02/05)
An efficient synthesis of 3-nitroimidazo[1,2-a]pyridines has been developed via N-iodosuccinimide (NIS)-mediated multicomponents reaction of 2-aminopyridines, aldehydes, and nitromethane under metal-free conditions. This protocol has many advantages such as broad substituent scope, mild and eco-friendly conditions, high step economy, and good yields.
Metal-free oxidative coupling of aminopyridines with nitroolefins to imidazo [1,2-α]pyridine in the presence of i2-tbhp-pyridine
An, Litao,Sun, Xiaojun,Lv, Meng,Zhou, Jianfeng,Zhu, Fengxia,Zhong, Hui
, p. 141 - 147 (2016/04/26)
A facile metal-free approach to the synthesis of imidazo [1,2-α]pyridine was developed through a tandem reaction of Michael addition and oxidative coupling. Iodine-t-butyl hydroperoxide-pyridine was found to be a green and efficient catalytic system for t
Synthesis of imidazo [1, 2 - α] pyridine derivatives of a simple method for
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Paragraph 0040-0043, (2019/02/02)
The invention relates to a simple method for synthesizing imidazo (1,2-a) pyridine derivatives. The method comprises the steps of: dissolving reactants including 2-aminopyridine or derivatives thereof and beta-nitrostyrolene or derivatives thereof into a
Magnetic carbon nanotube supported Cu (CoFe2O4/CNT-Cu) catalyst: A sustainable catalyst for the synthesis of 3-nitro-2-arylimidazo[1,2-a]pyridines
Zhang, Mo,Lu, Jun,Zhang, Jia-Nan,Zhang, Zhan-Hui
, p. 26 - 32 (2016/02/23)
A magnetic carbon nanotube supported Cu catalyst (CoFe2O4/CNT-Cu) was prepared, characterized and evaluated as a recoverable catalyst for synthesis of 3-nitro-2-arylimidazo[1,2-a]pyridines via one-pot three-component reactions of 2-a
Metal-free synthesis of imidazopyridine from nitroalkene and 2-aminopyridine in the presence of a catalytic amount of iodine and aqueous hydrogen peroxide
Tachikawa, Yuma,Nagasawa, Yoshitomo,Furuhashi, Sohei,Cui, Lei,Yamaguchi, Eiji,Tada, Norihiro,Miura, Tsuyoshi,Itoh, Akichika
, p. 9591 - 9593 (2015/03/03)
We have developed a metal-free synthetic method for 3-nitroimidazo[1,2-a]pyridines from nitroalkenes and 2-aminopyridines using catalytic amounts of iodine and aqueous hydrogen peroxide as a terminal oxidant.
Synthesis of 3-Nitro-2-arylimidazo[1,2- a ]pyridines Using Sodium Dichloro?-iodide
Jagadhane, Prashant B.,Telvekar, Vikas N.
, p. 2636 - 2638 (2015/01/09)
Moderate to good yields of various 3-nitro-2-arylimidazo[1,2-a]pyridines have been easily achieved in the reaction of 2-aminopyridines and nitrostyrenes in the presence of sodium dichloriodide. The procedure is simple and various functional groups are tol
Synthesis of 3-nitro-2-arylimidazo[1,2- a ]pyridines using sodium dichloro-iodide
Jagadhane, Prashant B.,Telvekar, Vikas N.
, (2015/08/06)
Moderate to good yields of various 3-nitro-2-arylimidazo[1,2-a]pyridines have been easily achieved in the reaction of 2-aminopyridines and nitrostyrenes in the presence of sodium dichloriodide. The procedure is simple and various functional groups are tol
Bu4NI-catalyzed synthesis of imidazo[1,2- a ]pyridines via oxidative coupling of aminopyridines with nitroolefins
Xu, Xiangsheng,Hu, Peizhu,Yu, Wubin,Hong, Guo,Tang, Yucai,Fang, Mingwu,Li, Xiaoqing
, p. 718 - 720 (2014/04/03)
A metal-free method for the synthesis of imidazo[1,2-a]pyridines via double C-N oxidative coupling of aminopyridines with nitroolefins using TBAI as the catalyst and TBHP as oxidation agent has been developed. Georg Thieme Verlag Stuttgart. New York.
Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a] pyridine: Expanding structural diversity of C2- and C3-functionalized imidazo[1,2-a]pyridines
Bazin, Marc-Antoine,Marhadour, Sophie,Tonnerre, Alain,Marchand, Pascal
, p. 5378 - 5382 (2013/09/12)
Alternative strategies for functionalizing 2-chloro-3-nitroimidazo[1,2-a] pyridine have been developed. Suzuki-Miyaura cross-coupling reaction provided easily the corresponding 2-arylated compounds, and herefrom the nitro group was reduced into amine which afforded amides, anilines, and ureas in the 3-position. The amination of the key compound using a metal-catalyzed reaction was reported. This study highlighted the importance of the nitro group to facilitate the chlorine displacement. Other nucleophilic aromatic substitutions open a route to various products derived from imidazo[1,2-a]pyridine.
