1705-89-1Relevant articles and documents
Ring-closure reaction of 2-benzoylbenzenediazonium salts in 1-butyl-3- methylimidazolium ionic liquids
Okazaki, Takao,Yamamoto, Hiroyuki,Kitagawa, Toshikazu
, p. 50 - 59 (2018/02/07)
A ring-closure reaction by thermal dediazoniation of 2-substituted benzenediazonium tetrafluoroborates in imidazolium-based ionic liquids was investigated. Dediazoniation of 2-(4-R-benzoyl)benzenediazonium tetrafluoroborates (R = H, Me, OMe, Cl) in ionic liquid [BMIM][TfO] gave 3-R-9-fluorenones as ring-closure products and 2-(4-R-benzoyl)phenyl trifluoromethanesulfonates as substitution products. Dediazoniation in [BMIM][Tf2N] afforded 3-R-9-fluorenones and R-C6H4-CO-C6H4-OSO(CF3)(NSO2CF3). Yields of the ring-closure products were higher in [BMIM][Tf2N] than in [BMIM][TfO]. 2-Benzylbenzenediazonium and 2-phenoxybenzenediazonium tetrafluoroborates exclusively produced substitution products in both ionic liquids. DFT calculations suggest that electron transfer from the anion to render homolytic process should be induced more readily in [BMIM][Tf2N] than in [BMIM][TfO]. This ability may be responsible for the higher yields of the ring-closure products via homolytic pathway and the smaller yields of the substitution products via heterolytic pathway in [BMIM][Tf2N].
Synthesis and cardiovascular properties of fluorenyl derivatives related to verapamil
Novella Romanelli,Teodori,Scapecchi,Dei,Budriesi,Chiarini
, p. 1121 - 1138 (2007/10/02)
A series of fluorenyl analogues of verapamil were synthesized and their cardiovascular properties on guinea pig isolated atria and isolated perfused heart evaluated. The compounds were also tested for their calcium antagonistic activity on guinea pig aort
