494749-16-5Relevant academic research and scientific papers
Synthesis of a heptaarylisoquinoline: Unusual disconnection for constructing isoquinoline frameworks
Asako, Takashi,Suzuki, Shin,Itami, Kenichiro,Muto, Kei,Yamaguchi, Junichiro
, p. 968 - 970 (2018/08/24)
In a novel disconnection of isoquinoline ring synthesis at the C7C8/C4aC8a bonds, these bonds can be formed by a [4+2] cycloaddition between thiophene S,S-dioxide and alkynes. With a subsequent CH arylation of the resulting hexaarylisoquinoline at the C3 position, the synthesis of a fully substituted isoquinoline has been achieved.
KMnO4-mediated direct C2-selective C?H arylation of quinoline N-oxides with aromatic hydrazines
Yuan, Jin-Wei,Li, Wei-Jie,Xiao, Yong-Mei
, p. 179 - 186 (2016/12/23)
An efficient protocol for the synthesis of 2-arylquinoline N-oxides has been developed via KMnO4-mediated cross-coupling reaction of quinoline N-oxides with aromatic hydrazines in moderated to good yields. The reactions proceeded efficiently over a broad range of substrates with excellent regioselectivity and functional group tolerance.
Regioselective decarboxylative cross-coupling of carboxy isoquinoline N -oxides
Rouchet, Jean-Baptiste E. Y.,Schneider, Cédric,Fruit, Corinne,Hoarau, Christophe
, p. 5919 - 5927 (2015/06/16)
A straightforward method for direct decarboxylative arylation of 1- and 3-carboxy isoquinaldic acid N-oxides with aryl iodides is reported. The reaction proceeded selectively at the carboxy function site to exclusively give the corresponding C-1/sub
Pd-catalyzed decarboxylative cross-coupling of 2-carboxyazine N-oxides with various (hetero)aryl halides
Rouchet, Jean-Baptiste,Schneider, Cedric,Spitz, Cedric,Lefevre, Johan,Dupas, George,Fruit, Corinne,Hoarau, Christophe
supporting information, p. 3610 - 3615 (2014/04/03)
Decarboxylative cross-coupling reactions of substituted 2-carboxyazine N-oxides, with a variety of (hetero)aryl halides, by bimetallic Pd 0/CuI and Pd0/AgI catalysis are reported. Two possible pathways, a conven
Direct arylation of azine N-oxides with aryl triflates
Schipper, Derek J.,El-Salfiti, Mohamed,Whipp, Christopher J.,Fagnou, Keith
experimental part, p. 4977 - 4983 (2009/10/17)
Palladium catalyzed direct arylation of azine N-oxides using aryl triflates to afford the corresponding 2-aryl azine N-oxides is described. The reaction is carried out with a range of both N-oxides and aryl triflates. The arylation can be carried out in s
