495-84-1

Usage

Brand name

Salizid (Parke-Davis).

Purification Methods

Crystallise it from EtOH (m 265-266o or 244-245o), aqueous EtOH or MeOH (252-253o) and dry it in a vacuum at 100o. [Beilstein 22 III/IV 584.]

InChI:InChI=1/C13H11N3O2/c17-12-4-2-1-3-11(12)9-15-16-13(18)10-5-7-14-8-6-10/h1-9,17H,(H,16,18)/b15-9+

Upstream product

• 54-85-3 isoniazid 
• 90-02-8 salicylaldehyde 
• 89-95-2 2-methyl-benzyl alcohol 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 98018-50-9 2-boronobenzaldehyde isonicotinoyl hydrazone 
• 55-22-1 pyridine-4-carboxylic acid 
• 380151-85-9 2-(2'-formylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1570-45-2 isonicotinic acid ethylester 

Downstream Products

• 112020-92-5 2-(2-hydroxyphenyl)-5-(4-pyridyl)-1,3,4-oxadiazole 
• 129890-68-2 {Ag(C₇H₆ONNH(CO)C₅H₄N)2ClO₄} 
• 155642-16-3 bis(isonicotinamidosalicylaldimine)diacetatodioxouranium(VI) 
• 155642-09-4 bis(isonicotinamidosalicylaldimine)tetraisothiocyanatothorium(IV) 
• 155642-14-1 bis(isonicotinamidosalicylaldimine)dinitratodioxouranium(VI) 
• 155642-12-9 bis(isonicotinamidosalicylaldimine)dibromodioxouranium(VI) 
• 155642-05-0 bis(isonicotinamidosalicylaldimine)tetrachlorothorium(IV) 

Relevant academic research and scientific papers

Evaluation of the cell cytotoxicity and DNA/BSA binding and cleavage activity of some dioxidovanadium(V) complexes containing aroylhydrazones

Three dioxidovanadium(V) complexes [VO2L1-3] (1-3) [HL1 = 1-napthoyl hydrazone of 2-acetyl pyridine, HL2 = 2-furoyl hydrazone of 2-acetyl pyridine and H2L3 = isonicotinoyl hydrazone of 2-hy

Synthesis, characterization and structural studies of diorganotin(IV) complexes with Schiff base ligand salicylaldehyde isonicotinylhydrazone

Eight diorganotin(IV) complexes of salicylaldehyde isonicotinylhydrazone (H2SalN) R2Sn(SalN) R = t-Bu 1, Ph 2, PhCH2 3, o-ClC6H4CH2 4, p-ClC6H 4CH2 5, m-ClC

Antiproliferative and antioxidative effects of novel hydrazone derivatives bearing coumarin and chromene moiety

[InlineMediaObject not available: see fulltext.] A series of new hybrid molecules with a hydrazone fragment were synthesized and characterized by Fourier transform-infrared spectroscopy, nuclear magnetic resonance, mass spectrometry, and elemental analysi

Field enhanced thermally activated mechanism in a square Dy4 aggregate

A rare μ4-OH centred square Dy4 aggregate displays a field enhanced thermally activated mechanism with 3-fold increase in the single-molecule magnetic relaxation barrier upon application of an optimal field. The Royal Society of Chem

The interaction of pyridoxal isonicotinoyl hydrazone (PIH) and salicylaldehyde isonicotinoyl hydrazone (SIH) with iron

The interaction of pyridoxal isonicotinoyl hydrazone (PIH) and salicylaldehyde isonicotinoyl hydrazone (SIH), two important biologically active chelators, with iron has been investigated by spectrophotometric methods. High iron(III) affinity constants were determined for PIH, logβ2 = 37.0 and SIH, logβ2 = 37.6. The associated redox potentials of the iron complexes were determined using cyclic voltammetry at pH 7.4 as + 130 mV (vs normal hydrogen electrode, NHE) for PIH and + 136 mV(vs NHE) for SIH. These redox potentials are much higher than those corresponding to iron chelators in clinical use, namely deferiprone, ? 620 mV; desferasirox, ? 600 mV and desferrioxamine, ? 468 mV. Although the positive redox potentials of SIH and PIH are similar to that of EDTA, namely + 120 mV, the iron complexes of these two hydrazone chelators, unlike the iron complex of EDTA, do not redox cycle in the presence of vitamin C. These properties render PIH and SIH as excellent scavengers of iron, under biological conditions. Both SIH and PIH scavenge mononuclear iron(II) and iron(III) rapidly. These fast kinetic properties of the hydrazone-based chelators provide a ready explanation for the adoption of SIH in fluorescence-based methods for the quantification of cytosolic iron(II).

Biochemical relevance of Cr(III) complexes of isoniazid: synthesis, characterization, DFT, antibacterial screening, antioxidant activity and glucose-lowering effect in STZ-induced diabetic rats

Molecular mechanism suggests that the incorporation of an antioxidant organic moiety to chromium will be a sound strategy for the synthesis of safer and more effective hypoglycemic compounds. Two Schiff base ligands were derived by condensation of isonico

The hydrolytic susceptibility of prochelator BSIH in aqueous solutions

The prochelator BSIH ((E)-N′-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylidene)isonicotinohydrazide) contains a boronate group that prevents metal coordination until reaction with peroxide releases the iron chelator SIH ((E)-N′-(2-hydroxybenzyli

A novel 2D vanadium(V)-isonicotinohydrazide coordination polymer, C 15H16AgN4O8V: Synthesis, structure, catalytic activity and DFT calculation

A novel two-dimensional 3d-4d transition metal-based coordination polymer [VO(OCH3)(OHCH3)(L)Ag(NO3)]∞ (1) has been synthesized and characterized by single crystal X-ray diffraction and fluorescence spectroscopy

Spectroscopic, molecular docking and structural activity studies of (E)-N′-(substituted benzylidene/methylene) isonicotinohydrazide derivatives for DNA binding and their biological screening

Acid catalyzed condensation of isoniazid with a number of suitably substituted aromatic and heterocyclic aldehydes was carried out in dry ethanol to afford the title (E)-N′-(substituted benzylidene/methylene) isonicotinohydrazides (SF 1 – SF 4) in good yi

A pro-chelator triggered by hydrogen peroxide inhibits iron-promoted hydroxyl radical formation

The synthesis and structural characterization of a new pro-chelating agent, isonicotinic acid [2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzylidene]-hydrazide (BSIH), are presented. BSIH only weakly interacts with iron unless hydrogen peroxide (H