495418-34-3Relevant academic research and scientific papers
Synthesis of α,α-difluoro-β-hydroxy ketone via the La(OTf)3-catalyzed aldol reaction of carbonyl compounds with difluoroenol O-Boc esters
Sasaki, Shigeru,Suzuki, Tatuo,Uchiya, Toshihiro,Toyota, Shigenobu,Hirano, Akira,Tanemura, Mao,Teramoto, Hiroyoshi,Yamauchi, Takayasu,Higashiyama, Kimio
, p. 78 - 85 (2016)
We herein present an efficient method for the construction of α,α-difluoro-β-hydroxy ketones. The La(OTf)3-catalyzed aldol reaction between difluoroenol O-Boc (Boc?=?tert-butyloxycarbonyl) esters and carbonyl compounds affords α,α-difluoro-β-hy
Decarboxylative aldol reaction of α,α-difluoro-β-ketocarboxylate salt: A facile method for generation of difluoroenolate
Tarui, Atsushi,Oduti, Mayuna,Shinya, Susumu,Sato, Kazuyuki,Omote, Masaaki
, p. 20568 - 20575 (2018/06/14)
We developed a decarboxylative aldol reaction using α,α-difluoro-β-ketocarboxylate salt, carbonyl compounds, and ZnCl2/N,N,N′,N′-tetramethylethylenediamine. The generation of difluoroenolate proceeded smoothly under mild heating to provide α,α-
A new sequential defluorination route to α-fluoro-α,β-unsaturated ketones from trifluoromethyl ketones
Hata, Hiroshi,Kobayashi, Takeshi,Amii, Hideki,Uneyama, Kenji,Welch, John T.
, p. 6099 - 6102 (2007/10/03)
α-Fluoro-α,β-unsaturated ketones were prepared from trifluoromethyl ketones via a sequence involving Mg metal promoted successive double defluorination. Trifluoromethyl ketones were transformed to β,β-difluoroenol silyl ethers which were then coupled with
