49714-52-5

Basic information

• Product Name: 2,2,3-TRIMETHYLBUTANOIC ACID
• Synonyms: 2,2,3-TRIMETHYLBUTANOIC ACID;2,2,3-trimethylbutyric acid;EINECS 256-441-6;Butanoic acid, 2,2,3-triMethyl-
• CAS NO: 49714-52-5
• Molecular Formula: C₇H₁₄O₂
• Molecular Weight: 130.18
• EINECS: 256-441-6
• Mol File: 49714-52-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 203.6°Cat760mmHg
• Flash Point: 88.5°C
• Appearance: /
• Density: 0.935g/cm³
• Vapor Pressure: 0.113mmHg at 25°C
• Refractive Index: 1.43
• CAS DataBase Reference: 2,2,3-TRIMETHYLBUTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,3-TRIMETHYLBUTANOIC ACID(49714-52-5)
• EPA Substance Registry System: 2,2,3-TRIMETHYLBUTANOIC ACID(49714-52-5)

Safety Data

• Hazardous Substances Data: 49714-52-5(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 70, p. 3793, 1948 DOI: 10.1021/ja01191a074

InChI:InChI=1/C7H14O2/c1-5(2)7(3,4)6(8)9/h5H,1-4H3,(H,8,9)

Upstream product

• 4168-01-8 2,2,3-trimethyl-3-butenoic acid 
• 625-65-0 2,4-dimethyl-2-pentene 
• 6968-27-0 2,2,3-trimethyl-butyric acid amide 
• 70250-61-2 3,3,4-trimethyl-3H-furan-2-one 
• 563-79-1 2,3-Dimethyl-2-butene 
• 5340-47-6 3,3,4-trimethylpentan-2-one 
• 7697-37-2 nitric acid 
• 124-38-9 carbon dioxide 
• 7664-93-9 sulfuric acid 
• 1727-57-7 2,2,3-trimethylbutansaeuremethylester 
• 160115-34-4 benzyl 2,2-dimethyl-3-oxobutanoate 
• 1727-61-3 ethyl 2,2,3-trimethylbutanoate 
• 79-29-8 2,3-dimethylbutane 
• 64-18-6 formic acid 

Downstream Products

• 55505-23-2 2,2,3-trimethylbutan-1-ol 
• 101419-71-0 1-bromo-2,2,3-trimethylbutane 
• 1610455-72-5 N-(4-cyano-2,3,5,6-tetrafluorophenyl)-2,2,3-trimethylbutanamide 
• 58265-35-3 2,2,3-trimethyl-butyric acid anilide 
• 5340-81-8 2,2,3,3,5,5,6-heptamethyl-heptan-4-one 
• 6968-27-0 2,2,3-trimethyl-butyric acid amide 
• 485819-07-6 2,2,3-Trimethyl-1-phenylbutan-1-ol 
• 51556-13-9 2,2,3-Trimethyl-1-phenylbutan-1-on 

Relevant articles and documents

Nickel-Catalyzed Addition-Type Alkenylation of Unactivated, Aliphatic C-H Bonds with Alkynes: A Concise Route to Polysubstituted γ-Butyrolactones

(Chemical Equation Presented). Through the nickel-catalyzed chelation-assisted C-H bond activation strategy, the addition-type alkenylation of unreactive β-C(sp3)-H bonds of aliphatic amides with internal alkynes is developed for the first time to produce γ,δ-unsaturated carboxylic amide derivatives. The resulting alkenylated products can further be transformed into polysubstituted γ-butyrolactones with pyridinium chlorochromate (PCC).

Analogs of isovaleramide, a pharmaceutical composition including the same, and a method of treating central nervous system conditions or diseases

An isovaleramide analog having at least one of an increased potency, an increased half-life, and an increased stability compared to isovaleramide. The isovaleramide analog is a cyclic analog or a noncyclic analog. The isovaleramide analog is formulated into a pharmaceutical composition. A method of treating a central nervous system condition or disease is also disclosed. The method comprises administering an isovaleramide analog to a patient suffering from the central nervous system condition or disease.