500315-91-3

Basic information

• Product Name: toluene-4-sulfonic acid-[2-(3,4-dimethyl-benzoyl)-anilide]
• CAS NO: 500315-91-3
• Molecular Weight: 379.48
• Mol File: 500315-91-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: toluene-4-sulfonic acid-[2-(3,4-dimethyl-benzoyl)-anilide](CAS DataBase Reference)
• NIST Chemistry Reference: toluene-4-sulfonic acid-[2-(3,4-dimethyl-benzoyl)-anilide](500315-91-3)
• EPA Substance Registry System: toluene-4-sulfonic acid-[2-(3,4-dimethyl-benzoyl)-anilide](500315-91-3)

Safety Data

• Hazardous Substances Data: 500315-91-3(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 118-92-3 anthranilic acid 
• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 
• 95-47-6 o-xylene 
• 42840-02-8 2-(Toluene-4-sulfonylamino)-benzoyl chloride 

Downstream Products

• 4627-17-2 2,3-dimethyl-9H-fluoren-9-one 
• 500870-84-8 2-N-(4-aminosulfonylbenzoyl)-amide-3',4'-dimethyl-benzophenone 
• 500870-83-7 2-N-(4-methylsulfonylbenzoyl)-amide-3',4'-dimethyl-benzophenone 
• 412296-63-0 2-amino-3',4'-dimethyl-benzophenone 

Relevant articles and documents

Synthesis and biological evaluation of substituted 2-sulfonyl-phenyl-3-phenyl-indoles: A new series of selective COX-2 inhibitors

A new series of substituted 2-sulfonyphenyl-3-phenyl-indole derivatives were synthesized and evaluated for their ability to inhibit COX-2 and COX-1enzymes. Most of the compounds synthesized were found to be highly potent and selective inhibitors of COX-2. This work led to the discovery of 2-aminosulfonylphenyl-3-phenyl-indole 5a which possesses higher activity and selectivity for COX-2 than Celecoxib both in vitro and in vivo.