501682-73-1

Basic information

• Product Name: 2-Propenoic acid, 3-[4-[(phenylsulfonyl)amino]phenyl]-, (2E)-
• CAS NO: 501682-73-1
• Molecular Formula: C15H13NO4S
• Molecular Weight: 303.339
• Mol File: 501682-73-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-[4-[(phenylsulfonyl)amino]phenyl]-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-[4-[(phenylsulfonyl)amino]phenyl]-, (2E)-(501682-73-1)
• EPA Substance Registry System: 2-Propenoic acid, 3-[4-[(phenylsulfonyl)amino]phenyl]-, (2E)-(501682-73-1)

Safety Data

• Hazardous Substances Data: 501682-73-1(Hazardous Substances Data)

Upstream product

• 21226-24-4 4-(benzenesulfonylamino)phenyl iodide 
• 79-10-7 acrylic acid 
• 6163-58-2 tris-(o-tolyl)phosphine 
• 98-09-9 benzenesulfonyl chloride 
• 540-37-4 p-aminoiodobenzene 

Downstream Products

• 1035211-01-8 3-(4-benzenesulfonylamino-phenyl)-N-(tetrahydro-pyran-2-yloxy)-propionamide 
• 342373-30-2 3-(4-benzenesulfonylamino-phenyl)-propionic acid 

Relevant articles and documents

Inhibitors of histone deacetylase

The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

Design and synthesis of a novel class of histone deacetylase inhibitors.

Histone deacetylase inhibitors (HDACs) have emerged as a novel class of antiproliferative agents. Utilizing structure-based design, the synthesis of a series of sulfonamide hydroxamic acids is described. Further optimization of this series by substitution of the terminal aromatic ring yielded HDAC inhibitors with good in vitro and in vivo activities.