5021-59-0

Basic information

• Product Name: 4-chloro-N-(4-fluorophenyl)benzamide
• Synonyms: 4-chloro-N-(4-fluorophenyl)benzamide
• CAS NO: 5021-59-0
• Molecular Formula: C₁₃H₉ClFNO
• Molecular Weight: 249.6680632
• Mol File: 5021-59-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 315.5°C at 760 mmHg
• Flash Point: 144.6°C
• Appearance: /
• Density: 1.353g/cm³
• Vapor Pressure: 0.000435mmHg at 25°C
• Refractive Index: 1.669
• PKA: 12.12±0.70(Predicted)
• CAS DataBase Reference: 4-chloro-N-(4-fluorophenyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-(4-fluorophenyl)benzamide(5021-59-0)
• EPA Substance Registry System: 4-chloro-N-(4-fluorophenyl)benzamide(5021-59-0)

Safety Data

• Hazardous Substances Data: 5021-59-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H10N2O2S/c1-12(10(13)14-2)9-11-7-5-3-4-6-8(7)15-9/h3-6H,1-2H3

Upstream product

• 201230-82-2 carbon monoxide 
• 1679-18-1 4-Chlorophenylboronic acid 
• 371-40-4 4-fluoroaniline 
• 371-14-2 4-fluorophenylhydrazine 
• 6833-15-4 4-chlorobenzanilide 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 1034134-97-8 4-chloro-N-(6-chloro-pyridin-3-yl-methyl)-N-(4-fluorophenyl)-benzamide 
• 1034136-08-7 4-chloro-N-(4-fluorophenyl)-N-(2-piperidin-1-yl-thiazol-4-yl-methyl)-benzamide 

Relevant articles and documents

Synthesis of Secondary Amides through the Palladium(II)-Catalyzed Aminocarbonylation of Arylboronic Acids with Amines or Hydrazines and Carbon Dioxide

A new Pd-catalyzed aminocarbonylation of arylboronic acids with amines or phenylhydrazines has been developed. Various secondary amides were produced from readily available substrates and cheap common metal catalysts in a CO atmosphere (balloon). Remarkably, we presents the first example of aminocarbonylations between arylboronic acids and phenylhydrazines.

Hypervalent iodine mediated para -selective fluorination of anilides

A metal-free method for the direct regioselective fluorination of anilides has been developed. In the presence of bis(tert-butylcarbonyloxy)iodobenzene (PhI(OPiv)2) and hydrogen fluoride-pyridine, the para-fluorination products of anilides were obtained in moderate to good yields. Because of its operational safety and the use of readily available reagents, this new procedure provides facile access to a variety of para-fluorinated anilides.

CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS

The present teachings provide compounds of Formula (I) wherein Ar, R1, R2, R3, X, p and n are defined herein. The present teachings also provide processes for producing said compounds and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.