5031-71-0Relevant academic research and scientific papers
Pd/C-Catalyzed Domino Synthesis of Urea Derivatives Using Chloroform as the Carbon Monoxide Source in Water
Wang, Liang,Wang, Hao,Li, Guiqing,Min, Shuliang,Xiang, Fangyuan,Liu, Shiqi,Zheng, Waigang
, p. 4585 - 4593 (2018/10/31)
A Pd/C-catalyzed domino synthesis of symmetrical and unsymmetrical ureas from aryl iodides, sodium azide, amines and CHCl3 in water has been developed. This reaction proceeds with sequential carbonylation, Curtius rearrangement and nucleophilic addition. CHCl3 serves as a convenient and safe alternation of CO gas in the presence of KOH. A series of urea derivatives were obtained in moderate to good yields with good functional group tolerance. Furthermore, the Pd/C catalyst could be readily recovered with slight decrease in the catalytic activity after six consecutive runs. (Figure presented.).
An efficient synthesis of nitrile, tetrazole and urea from carbonyl compounds
Sribalan, Rajendran,Sangili, Arumugam,Banuppriya, Govindharasu,Padmini, Vediappen
, p. 3414 - 3421 (2017/07/13)
An efficient conversion of carbonyl compounds (aldehydes and ketones) to nitrile, tetrazole, and urea was developed with the use of a POCl3 and sodium azide mixture using a convergent and microwave method. This is the first report on the direct conversion of ketone to urea. The synthesized compounds were characterized by 1H NMR, 13C NMR, mass and IR spectroscopies and were found to be in agreement with reported compounds.
N, N '-asymmetric diaryl-substituted urea compound and its preparation and use
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Paragraph 0088-0090, (2017/03/08)
The invention relates to N,N'-asymmetric diayl substitution urea compound of a general formula (I). A and B independently represent aryl, one-substitution or multi-substitution aryl, miscellaneous aryl and one-substitution or multi-substitution miscellaneous aryl. R1 and R2 independently represent hydrogen or C1-C8 alkyl or C1-C8 alkoxy or aromatic alkoxy or acyl or non-aromatic heterocycle substitution group or halogen or nitryl or trifluoromethyl or cyan. The invention further relates to a preparation method of the compound, active component medicine composition of the compound and application of the compound in preparing medicine for restraining new delhi metallo beta-lactamase (NDM-1) drug-resistant bacteria.
Synthesis of unsymmetrical ureas and S-thiocarbamates under catalyst-free conditions in a [BMIM]BF4 ionic liquid
Hosseinzadeh, Rahman,Tajbakhsh, Mahmood,Aghili, Nora
, p. 175 - 182 (2015/05/27)
Unsymmetrical ureas and Sthiocarbamates were prepared in good to excellent yields by direct condensation of phenylurea with amines and thiols in 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM]BF4) without the addition of any additives. The [BMIM]BF4 ionic liquid is a mild medium and can be recycled and reused several times.
NMR method for simultaneous host-guest binding constant measurement
Kadam, Sandip A.,Haav, Kristjan,Toom, Lauri,Haljasorg, Toiv,Leito, Ivo
, p. 2501 - 2513 (2014/04/17)
An NMR-based relative binding affinity measurement method has been developed in which differences in the binding affinities of different hosts toward a particular guest (ΔlogKass values) are measured in the same solution. As an advancement, the
Cu(acac)2-catalyzed N-arylations of phenylurea with aryl boronic acid
Gavade, Sandip,Balaskar, Ravi,Mane, Madhav,Pabrekar, Pramod N.,Mane, Dhananjay
experimental part, p. 1704 - 1714 (2012/05/05)
Cu(acac)2 activates aryl boronic acids for the reaction with NH2-phenylurea without additional ligand and heating. The procedure is simple, general, ligand-free, milder than the palladium-catalyzed arylation, and avoids the use of toxic phosphine ligands. Copyright Taylor & Francis Group, LLC.
An efficient method for the N-arylation of phenylurea via copper catalyzed amidation
Gavade, Sandip N.,Balaskar, Ravi S.,Mane, Madhav S.,Pabrekar, Pramod N.,Shingare, Murlidhar S.,Mane, Dhananjay V.
experimental part, p. 675 - 678 (2012/01/13)
The coupling reaction of phenylurea with different functionalized aryl halides in the presence of air stable CuI, N,N-dimethylethylenediamine as a ligand, and K3PO4 as a base gives symmetrical and unsymmetrical diarylureas in relatively high yields. This method is milder than the palladium catalyzed arylation and avoids the use of toxic phosphine ligands.
Microwave assisted, solvent- and ligand-free copper catalyzed N-arylation of phenylurea with aryl halides
Gavade, Sandip,Shingare, Murlidhar,Mane, Dhananjay
experimental part, p. 4167 - 4170 (2012/02/16)
An inexpensive and efficient catalyst system has been developed for the N-arylation of phenylurea including a variety of aryl halides. This simple protocol uses Cu2O as the catalyst, microwave assisted, solvent- and ligand-free, K3PO4.H2O as the base.
Microwave assisted, ligand free, copper catalyzed reaction of aryl halides with phenyl urea
Gavade, Sandip N.,Balaskar, Ravi S.,Mane, Madhav S.,Pabrekar, Pramod N.,Shingare, Murlidhar S.,Mane, Dhananjay V.
experimental part, p. 292 - 295 (2012/01/05)
The ligand free coupling reaction of phenyl urea with different functionalized aryl halides in the presence of air stable Cu2O and t-BuOK as a base gives symmetrical and unsymmetrical diarylureas in relatively high yields. This method is milder than the palladium catalyzed arylation and avoids the use of toxic phosphine ligand.
An efficient and mild protocol for the synthesis of unsymmetrical ureas in the absence of catalyst and additives
Hosseinzadeh, Rahman,Sarrafi, Yaghoub,Aghili, Nora
experimental part, p. 1171 - 1174 (2011/10/04)
A new practical method for the synthesis of unsymmetrical ureas was achieved by reaction of phenylurea with primary and secondary amines under neutral and mild condition in very good yields. The reaction took place in refluxing dioxane and does not require any catalyst or additives.
