50496-61-2Relevant academic research and scientific papers
Silver-catalyzed stereoselective formation of glycosides using glycosyl ynenoates as donors
Dong, Xu,Chen, Li,Zheng, Zhitong,Ma, Xu,Luo, Zaigang,Zhang, Liming
supporting information, p. 8626 - 8629 (2018/08/06)
A silver-catalyzed glycosylation reaction employing readily accessible and stable glycosyl ynenoates is developed. This reaction is mostly high yielding and exhibits varying levels of stereoinversion at the anomeric position. Compared to established and versatile Yu's gold catalysis, this chemistry features the use of substantially cheaper AgNTf2.
Discovery of a novel series of N-hydroxypyridone derivatives protecting astrocytes against hydrogen peroxide-induced toxicity via improved mitochondrial functionality
Singh, Sarbjit,Goo, Ja-Il,Noh, Hyojin,Lee, Sung Jae,Kim, Myoung Woo,Park, Hyejun,Jalani, Hitesh B.,Lee, Kyeong,Kim, Chunsook,Kim, Won-Ki,Ju, Chung,Choi, Yongseok
supporting information, p. 1394 - 1405 (2017/02/18)
Astrocytes play a key role in brain homeostasis, protecting neurons against neurotoxic stimuli such as oxidative stress. Therefore, the neuroprotective therapeutics that enhance astrocytic functionality has been regarded as a promising strategy to reduce brain damage. We previously reported that ciclopirox, a well-known antifungal N-hydroxypyridone compound, protects astrocytes from oxidative stress by enhancing mitochondrial function. Using the N-hydroxypyridone scaffold, we have synthesized a series of cytoprotective derivatives. Mitochondrial activity assay showed that N-hydroxypyridone derivatives with biphenyl group have comparable to better protective effects than ciclopirox in astrocytes exposed to H2O2. N-hydroxypyridone derivatives, especially 11g, inhibited H2O2-induced deterioration of mitochondrial membrane potential and oxygen consumption rate, and significantly improved cell viability of astrocytes. The results indicate that the N-hydroxypyridone motif can provide a novel cytoprotective scaffold for astrocytes via enhancing mitochondrial functionality.
SilverCatalyzed Cascade Carboxylation and Cyclization of Trimethyl(2-methylenebut-3-yn-1-yl)silane Derivatives
Sekine, Kohei,Sadamitsu, Yuta,Yamada, Tohru
supporting information, p. 5706 - 5709 (2015/12/01)
C-C bond-forming carboxylation and cyclization of trimethyl(2-methylenebut-3-yn-1-yl)silane derivatives and carbon dioxide was developed. Silver catalysts and CsF promoted the reaction to afford the corresponding 2-furanone and 2-pyrone derivatives in goo
