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Usage

Uses

Used in Pesticide Industry:
1,5-Diphenyl-1H-1,2,4-triazole-3(2H)-thione is used as a pesticide for its ability to control and eliminate pests that can damage crops and reduce agricultural productivity. Its effectiveness in this application is attributed to its ability to disrupt the normal growth and development of pests, thereby protecting crops from infestation.
Used in Fungicide Industry:
In the fungicide industry, 1,5-Diphenyl-1H-1,2,4-triazole-3(2H)-thione is employed as a fungicidal agent to prevent and treat fungal infections in crops. Its antimicrobial properties enable it to inhibit the growth of fungi that can cause diseases in plants, thus ensuring a healthy and disease-free crop yield.
Used in Polymer Manufacturing:
1,5-Diphenyl-1H-1,2,4-triazole-3(2H)-thione is used as a photoinitiator in the manufacturing of polymers. Its ability to absorb light and generate reactive species makes it an effective initiator for the polymerization process, leading to the production of high-quality polymers with desired properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1,5-Diphenyl-1H-1,2,4-triazole-3(2H)-thione is utilized in the production of various drugs. Its potential antimicrobial, anticancer, and antiviral properties make it a promising candidate for the development of new treatments and therapies for a range of diseases and conditions.
Used as an Intermediate in Organic Synthesis:
1,5-Diphenyl-1H-1,2,4-triazole-3(2H)-thione is also used as an intermediate in organic synthesis, where it serves as a building block for the synthesis of more complex organic compounds. Its unique structure and reactivity make it a valuable component in the development of new chemical entities with potential applications in various fields.
However, it is crucial to handle and use 1,5-Diphenyl-1H-1,2,4-triazole-3(2H)-thione with caution, as it may have harmful effects on human health and the environment. Proper safety measures and regulations should be followed to minimize any potential risks associated with its use.

Upstream product

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Downstream Products

• 99793-67-6 1,5-diphenyl-3-<(tetrafluoroethyl)thio>-1H-1,2,4-triazole 
• 72234-23-2 1,5-diphenyl-3-methylthio-1,2,4-triazole 

Relevant academic research and scientific papers

Synthesis and antitumor effects of a new class of 1,2,4-triazole derivatives

In order to obtain more effective antitumor agents, a new class of 1,2,4-triazole derivatives bearing disulfide bond were designed and synthesized. All the final compounds were confirmed by IR, 1H NMR, 13C NMR and HR-ESI-MS. The in vitro cytotoxicity of the compounds on the SMMC-7721, Hela, A549 cancer cell lines and the L929 normal cell lines were assessed by cell counting kit-8 (CCK-8). Many of tested compounds 8a–h, 9a–h, 10a–h had better cytotoxic activity on various cancer cell lines than positive control 5-fluorouracil, and they were less cytotoxic to normal cell line L929 than cancer cells. Among them, compounds 9e, 9g, and 10h showed better cytotoxic activity on SMMC-7721 cells with IC50 values 4.12, 2.92, and 4.53 μM, respectively. Compounds 8a, 9g, 10g and 10h displayed high antiproliferative activity against Hela cells with IC50 values 6.31, 4.31, 6.31 and 3.97 μM, respectively. Compounds 8c, 10a and 10h revealed effective biological potency on A549 cells with IC50 values 4.75, 4.92 and 3.73 μM, respectively. Moreover, a great majority of tested compounds revealed low cytotoxicity on normal cell line L929.

Nano nickel [1,2,4]-triazole-3-thiones complex: Design, sonochemical synthesis, and antimicrobial evaluation

A series of new 1,2,4-triazole-3-thiones were synthesized by calm, benign, no risk, eco-friendly, and energy efficient sequential reaction methodology like grinding and ultrasonic (US). In addition, 1,2,4-triazoles were prepared under conventional method and comparative study was done. The synthesized 1,2,4-triazoles were complexed with Ni(II) to produce nanoparticles complexes (NPC's) with average particle size vary from 55 to 100 nm (using scanning electron microscope technique) with good yields via both US and conventional techniques. X-ray diffraction technique and spectra analysis techniques were used to confirm the square planer geometry of the synthesized NPC's. Antimicrobial activity of the prepared 1,2,4-triazoles and their nickel complexes were studied which evaluated a high activity with complexes instead their triazoles.

Synthesis and antitumor activity evaluation of some novel pyrazolotriazine derivatives

6-Aminopyrazolo[1,2-a][1,2,4]triazine-4,8-dione derivative 3 was obtained upon the reaction of the acid hydrazide derivative 2a with ethyl cyanoacetate. The reactions of 3 with several electrophiles such as aldehydes, isatin, acetic anhydride, phenyl isoc

Preparation and antiarthritic activity of new 1,5-diaryl-3-alkylthio-1H-1,2,4-triazoles and corresponding sulfoxides and sulfones

A series of 1,5-diaryl-3-alkylthio-1H-1,2,4-triazoles and corresponding sulfoxides and sulfones was synthesized and evaluated as antiinflammatory agents in the rat adjuvant induced arthritis assay.Several analogues were found to be more potent than phenyl

STRUCTURE INVESTIGATIONS ON SOME DIPHENYLTRIAZOLES

Syntheses of 1,3-diphenyl-4H-1,2,4-triazolin-5-thione (1) and 1,5-diphenyl-2H-1,2,4-triazolin-3-thione (2) have been reinvestigated and the structures proposed in the literature corrected. 1H-NMR, 13C-NMR, UV and MS studies of these compounds and their S-