50597-88-1

Basic information

• Product Name: 3-IODO-4-METHOXYTOLUENE
• Synonyms: 2-Iodo-1-methoxy-4-methylbenzene;2-Iodo-1-methoxy-4-methyl-benzene;2-iodo-4-methyl-anisole;3-IODO-4-METHOXYTOLUENE;2-Iodo-4-methyl-1-methoxybenzene
• CAS NO: 50597-88-1
• Molecular Formula: C₈H₉IO
• Molecular Weight: 248.06
• Mol File: 50597-88-1.mol
• Article Data: 38

Chemical Properties

• Melting Point: 28-30°C
• Boiling Point: 86°C 1mm
• Flash Point: 109.6 °C
• Appearance: /
• Density: 1.634 g/cm³
• Vapor Pressure: 0.0232mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-IODO-4-METHOXYTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IODO-4-METHOXYTOLUENE(50597-88-1)
• EPA Substance Registry System: 3-IODO-4-METHOXYTOLUENE(50597-88-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 50597-88-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H9IO/c1-6-3-4-8(10-2)7(9)5-6/h3-5H,1-2H3

Upstream product

• 120-71-8 Cresidine 
• 110-86-1 pyridine 
• 104-93-8 p-methylanizole 
• 7553-56-2 iodine 
• 7697-37-2 nitric acid 
• 7790-99-0 Iodine monochloride 
• 64-19-7 acetic acid 
• 25045-36-7 2-methoxy-5-methylbenzoic acid 
• 2432-18-0 2,6-diiodo-4-methylphenol 
• 74-88-4 methyl iodide 
• 51699-90-2 1,3-diiodo-2-methoxy-5-methylbenzene 

Downstream Products

• 1152781-31-1 C₁₁H₁₂O₂ 
• 1191950-68-1 1-methoxy-4-methyl-2-(2-phenylethynyl)benzene 
• 71289-36-6 1-(2-methoxy-5-methylphenyl)-1H-imidazole 
• 331270-35-0 N-(2-methoxy-5-methylphenyl)-4-methylbenzamide 
• 28219-46-7 N-(2-methoxy-5-methylphenyl)benzamide 
• 349122-21-0 N-(2-methoxy-5-methylphenyl)-4-chlorobenzenesulfonamide 
• 116-41-6 N-(2-methoxy-5-methylphenyl)-4-methylbenzenesulfonamide 
• 6964-02-9 N-(2-methoxy-5-methylphenyl)benzenesulfonamide 
• 262361-95-5 3-heptafluoroisopropyl-4-methoxybenzyl iodide 
• 262361-94-4 3-heptafluoroisopropyl-4-methoxybenzyl bromide 
• 1570511-10-2 (R)-2-(3-(benzyloxy)-1-phenylpropyl)-1-methoxy-4-methylbenzene 
• 69618-12-8 2,5-bis-(2'-methoxy-5'-methylphenyl)-furan 
• 20628-07-3 2-acetyl-4-methylanisole 

Relevant articles and documents

Protecting Group-Controlled Remote Regioselective Electrophilic Aromatic Halogenation Reactions

Being able to utilize a protecting group to influence remote regiocontrol offers a simple alternative approach to direct late-stage functionalization of complex organic molecules. However, protecting groups that have the ability to influence reaction regi

Facile and practical synthesis of π-extended oxepins by benzannulation and intramolecular cyclization

π-Extended oxepins 1 and dimer 8 were synthesized by the benzannulation of the corresponding asymmetric diarylacetylene derivatives and 2-(phenylethynyl)benzaldehyde followed by the Cu-catalyzed intramolecular cyclization. The optical properties of the π-extended oxepins 1 and 8 are also investigated.

N-Iodosuccinimide (NIS) in Direct Aromatic Iodination

N-Iodosuccinimide (NIS) in pure trifluoroacetic acid (TFA) offers a time-efficient and general method for the iodination of a wide range of mono- and disubstituted benzenes at room temperature, as demonstrated in this paper. The starting materials were generally converted into mono-iodinated products in less than 16 hours at room temperature, without byproducts. A few deactivated substrates needed addition of sulfuric acid to increase the reaction rate. Another exception was methoxybenzenes that preferentially were iodinated by NIS in acetonitrile with only catalytic amounts of TFA.