50638-50-1

Basic information

• Product Name: 4-BROMO-N,N-DIMETHYL-M-TOLUIDINE
• Synonyms: 4-BROMO-N,N-DIMETHYL-M-TOLUIDINE;4-BROMO-N,N,3-TRIMETHYLANILINE,98.0+%(GC)(T);BenzenaMine, 4-broMo-N,N,3-triMethyl-;4-Bromo-N,N,3-trimethylaniline
• CAS NO: 50638-50-1
• Molecular Formula: C₉H₁₂BrN
• Molecular Weight: 214.1
• Mol File: 50638-50-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 54 °C
• Boiling Point: 148 °C / 17mmHg
• Flash Point: 121.7°C
• Appearance: /
• Density: 1.339g/cm³
• Vapor Pressure: 0.00449mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-BROMO-N,N-DIMETHYL-M-TOLUIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-N,N-DIMETHYL-M-TOLUIDINE(50638-50-1)
• EPA Substance Registry System: 4-BROMO-N,N-DIMETHYL-M-TOLUIDINE(50638-50-1)

Safety Data

• Hazardous Substances Data: 50638-50-1(Hazardous Substances Data)

Usage

Uses

N,N-Dimethyl 4-bromo-3-methylaniline is a compound involved in the preparation of pyridinylpyrazoleacetonitriles and pyridinylpyrazoleacetamides as ROS receptor tyrosine kinase inhibitors.

InChI:InChI=1/C9H12BrN/c1-7-6-8(11(2)3)4-5-9(7)10/h4-6H,1-3H3

Upstream product

• 50-00-0 formaldehyd 
• 71642-16-5 3-methyl-2,4,6-tribromoaniline 
• 121-72-2 N,N-dimethyl-m-toluidine 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 7647-01-0 hydrogenchloride 
• 16518-64-2 3-(dimethylamino)benzoic acid methyl ester 
• 825-80-9 m-methyl-N,N-dimethylaniline-N-oxide 

Downstream Products

• 678986-46-4 5-bromo-2-dimethylamino-4-methyl-benzyl alcohol 
• 1421275-79-7 C₂₇H₂₉N₅O₂ 
• 1421275-68-4 C₂₇H₂₇N₅O 
• 1421275-63-9 N,N,3-trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine 
• 65399-14-6 4-(dimethylamino)-2-methylbenzoic acid 
• 1178884-09-7 6-(dimethylamino)-2-(2-(hydroxymethyl)-3-(1-methyl-5-(5-(morpholine-4-carbonyl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1462328-58-0 C₁₃H₁₉N₃O 
• 1242156-99-5 C₁₈H₁₇BrN₂O₂ 
• 1198765-28-4 C₃₄H₃₄N₆O₅ 
• 1462328-86-4 2-(3-chloro-2-(hydroxymethyl)phenyl)-6-(dimethylamino)-3,4-dihydroisoquinolin-1(2H)-one 
• 1462328-78-4 2-chloro-6-(6-dimethylamino-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)benzaldehyde 
• 1178884-33-7 6-dimethylamino-3,4-dihydro-2H-isoquinolin-1-one 
• 943635-05-0 4-(N,N-dimethylamino)-2-methylbenzamide 
• 1427470-72-1 C₉H₁₃NS 

Relevant articles and documents

Unreactive C-N Bond Activation of Anilines via Photoinduced Aerobic Borylation

Unreactive C-N bond activation of anilines was achieved by photoinduced aerobic borylation. A diverse range of tertiary and secondary anilines were converted to aryl boronate esters in moderate to good yields with wide functional group tolerance under simple and ambient photochemical conditions. This transformation achieved the direct and facile C-N bond activation of unreactive anilines, providing a convenient and practical route transforming widely available anilines into useful aryl boronate esters.

Making Dimethylamino a Transformable Directing Group by Nickel-Catalyzed C-N Borylation

The dimethylamino (Me2N) group is arguably the most versatile functional group capable of highly efficient and site-selective directed aromatic functionalizations at the ortho-, meta-, and para-positions depending on reaction conditions. While the repertoire of Me2N-directed reactions is growing at a rapid pace, the lack of a general method to transform this group to other functionalities hampers its wider application in organic synthesis. Here we report nickel-catalyzed C-N borylations of aryl- and benzyl-dimethylamines that permit the conversion of a huge library of largely underutilized Me2N-containing organic molecules into various functional molecules by taking advantage of the wealth of existing C-B functionalization methods.

(Hetero)-aryl ketones derivatives with antibacterial properties

Conformationally restricted aryl and heteroaryl ketones derived from monic acid have useful antibacterial properties.