507485-39-4Relevant academic research and scientific papers
A novel potent cell cycle inhibitor dehydrophenylahistin. - Enzymatic synthesis and inhibitory activity toward sea urchin embryo
Kanzaki, Hiroshi,Yanagisawa, Satohiro,Kanoh, Kaneo,Nitoda, Teruhiko
, p. 1042 - 1047 (2002)
A novel dehydrogenated cyclic dipeptide named as dehydrophenylahistin (APLH) was effectively prepared from a fungal metabolite (-)-phenylahistin by the enzymatic conversion catalyzed by the cell-free extract of Streptomyces albulus KO-23, an albonoursin-producing actinomycete. ΔPLH exhibited more than 1,000 times as high potent inhibitory activity toward the first cleavage of sea urchin embryos as (-)-phenylahisitn which has been reported to be a cell cycle inhibitor and more than 10,000 as high as albonoursin, indicating that ΔPLH is a promising leading compound for anticancer drugs.
ANALOGS OF DEHYDROPHENYLAHISTINS AND THEIR THEAPEUTIC USE
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Page/Page column 25-26, (2008/12/08)
Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.
