50776-29-9

Upstream product

• 20780-76-1 5-iodoisatin 
• 98-86-2 acetophenone 
• 100-52-7 benzaldehyde 
• 127-17-3 2-oxo-propionic acid 
• 540-37-4 p-aminoiodobenzene 

Downstream Products

• 181048-19-1 2-phenyl-6-iodoquinoline-4-carbonylguanidine 
• 1204211-92-6 N-[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]-6-iodo-2-phenylquinoline-4-carboxamide 
• 1204211-98-2 N-[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]-2,6-diphenylquinoline-4-carboxamide 

Relevant academic research and scientific papers

Facile synthesis of 2-phenylquinoline-4-carboxamide derivatives with variant structural features

The quinoline scaffold is an important class of heterocyclic compounds that possesses diverse chemotherapeutic activities. Thus, the 2-phenylquinoline-4- carboxamide derivatives containing a variety of moieties, such as 2-(2-furanyl)-1,3,4-oxadiazole, N-(2-methylphenyl)-4-(3-pyridinyl)-2- pyrimidinamine, 4,4′-bithiazole, purine, adamantine and resorcinol, have been designed and synthesized via Suzuki coupling, acid-base coupling and other typical reactions.

STAT3 INHIBITOR CONTAINING QUINOLINECARBOXAMIDE DERIVATIVE AS ACTIVE INGREDIENT

The present invention provides a STAT3 inhibitor containing as an active ingredient, a quinolinecarboxamide derivative represented by the formula (I) (in the formula, W represents a bond or an alkylene chain; X represents O, S, or NR34; and Rs