50781-81-2

Upstream product

• 57735-14-5 4-anilino-5-phenyl-2,4-dihydro-[1,2,4]triazol-3-one 
• 96133-99-2 C₁₀H₁₃N₃OS 
• 100-63-0 phenylhydrazine 
• 70249-85-3 carbethoxyhydrazone du benzoate d'ethyle 
• 5333-86-8 ethyl benzimidate hydrochloride 
• 65-85-0 benzoic acid 
• 75-15-0 carbon disulfide 
• 613-94-5 benzoic acid hydrazide 
• 38539-87-6 potassium 3-benzoyldithiocarbazinate 

Downstream Products

• 1333972-79-4 6-acetyl-3,5-diphenyl-8-(4-chlorophenyl)-5,8-dihydro-[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine 
• 1333972-73-8 (4-phenylamino-5-phenyl-1,2,4-triazol-3-yl)-N-(4-chlorophenyl)-2-oxopropane thiohydrazonate 
• 1333972-80-7 6-benzoyl-3,5,8-triphenyl-5,8-dihydro-[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine 
• 1333972-74-9 (4-phenylamino-5-phenyl-1,2,4-triazol-3-yl)-N-phenyl-2-oxo-2-phenylethane thiohydrazonate 
• 1333972-78-3 6-acetyl-3,5-diphenyl-8-(p-tolyl)-5,8-dihydro-[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine 
• 1333972-72-7 (4-phenylamino-5-phenyl-1,2,4-triazol-3-yl)-N-(4-tolyl)-2-oxopropane thiohydrazonate 
• 58106-84-6 anilino-4 phenyl-5 thioethyl-3 triazole-1,2,4 
• 156872-08-1 2-(4-anilino-5-phenyl-4H-1,2,4-triazol-3-yl)thio-1-phenylethanone 
• 1401315-33-0 3,5-diphenyl-8-thioxo-8,9-dihydro-5H-1,2,4-triazolo[4,3-b]-1,2,4-thiazepin-6(7H)-one 
• 1401315-32-9 3,5,8-triphenyl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazepin-6(5H)-one 
• 1401315-31-8 8-methyl-3,5-diphenyl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazepin-6(5H)-one 
• 1401315-30-7 3,5-diphenyl-5H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine-6,7-dione 
• 1401315-29-4 3,5-diphenyl-6,7-dihydro-5H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine 
• 1401315-21-6 3,5-diphenyl-5H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine-6(7H)-one 

Relevant academic research and scientific papers

Synthesis and antihyperlipidemic activity of some novel 4-(substitutedamino)-5-substituted-3-mercapto-(4H)-1,2,4-triazoles

Hyperlipidemia is considered one of the key factors for cardiovascular diseases. Based on earlier work on a series of 5-alkyl-4-aryl-3-mercapto-(4H)-1, 2,4-triazoles, for further lead modification, a series of 4-(substituted)amino- 5-substituted-3-mercapto-(4H)-1,2,4-triazoles was designed. Target compounds were synthesized by the well known Hoggarth synthesis of substituted 1,2,4-triazoles. Synthesized compounds were screened for lipid lowering activity using the "Poloxamer 407 induced hyperlipidemia in rats" model at a dose of 100 mg/kg p. o. Compounds were found to alter serum lipid levels significantly. Most of the compounds significantly reduced serum cholesterol and triglyceride levels. Some of the compounds were found to reduce triglycerides and elevate high density lipoprotein (HDL) levels more than the standard drug atorvastatin (CAS 134523-03-8). Compounds with chloro substitution on aryl rings were found more active in reducing serum lipid levels than other substitutions. ECV ? Editio Cantor Verlag.

Synthesis and antimicrobial activity of 1,2,4-triazolo[4,3-b][1,2,4,5] tetrazines

Synthesis of 4-phenylamino-5-phenyl-4H-[1,2,4]triazole-3-thiol (1) and 3-methylthio-4-phenylamino-5-phenyl-4H-[1,2,4]triazole (2) is described. Reactions of hydrazonoyl halides (3) with either 1 or 2 afforded 1,2,4-triazol[4,3-b][1,2,4,5]tetrazine. The la

Investigation on the reaction of 4-anilino-5-mercapto-s-triazoles with pyrazolines and barbituric acids

Synthesis of new 4-anilino-5-mercapto-3-substituted-1,2,4-triazoles (III) has been described.Reaction of III with 4,4-dibromo-substituted-pyrazolin-5-ones (VIII) affords 3,3'-substituted-5-phenyl-s-triazolothiadiazolidin-spiropyrazolin-5-ones

Derives de la dihydro-2,4 triazole-1,2,4 thione-3 et de l'amino-2 thiadiazole-1,3,4 a partir de nouvelles thiosemicarbazones d'esters

A new general synthesis of 4,5-disubstituted 2,4-dihydro-1,2,3-triazole-3-thiones is proposed.These heterocycles are obtained by the action of primary amines, aralhydrazines or aroylhydrazines on the thiosemicarbazones of esters.These last compounds are prepared by action of chlorhydrates of iminoesters on thiosemicarbazide in dimethylformamide.These thiosemicarbazones react also with strong acids, acid anhydrides and chlorides; by thermolysis and they give 2-amino-1,3,4-thiadiazole derivatives.Also, two derivatives of 1,2,4-triazolo-1,3,4-thiadiazole have been prepared.