51044-13-4Relevant articles and documents
Synthesis, structure and properties of a new two-photon photopolymerization initiator
Ren, Yan,Yu, Xiao-Qiang,Zhang, Dong-Ju,Wang, Dong,Zhang, Ming-Liang,Xu, Gui-Bao,Zhao, Xian,Tian, Yu-Peng,Shao, Zong-Shu,Jiang, Min-Hua
, p. 3431 - 3437 (2002)
A new two-photon free-radical photopolymerization initiator, (E,E)-4-{2-[p′-(N,N-di-n-butylamino)stilben-p-yl]vinyl} pyridine (abbreviated to DBASVP), has been synthesized. Quantum chemistry calculations showed that the new initiator possesses a large delocalized π electron system, a large change in dipole moment on transition to the excited state anda large transition moment. The calculated two-photon absorption cross-section is as high as 881.34 × 10-50 cm4 s photon-1. The single-photon and two-photon absorption and fluorescence properties in various solvents have been investigated carefully. The new initiator exhibits outstanding solvent-sensitivity, which experimentally interprets the excellent electron delocalized properties of the molecule. A microstructure has been fabricated under irradiation at 800 nm using a 200 fs, 76 MHz Ti:sapphire femtosecond laser.
Novel indole-based photosensitizers coupled with PEG-HEC quasi-solid-state electrolyte to improve energy conversion and stability of organic dyes based-dye sensitized solar cells
Santhosh, Kamaraj,Ganesan, Shanmugam,Balamurugan, Selvaraj
, (2021/07/13)
A series of novel Indole based organic dyes were synthesized and coupled with a Poly-ethylene glycol-Hydroxy ethyl cellulose quasi-solid-state-electrolyte (PEG-HEC QSSE) polymer blended iodine electrolyte to obtain a metal-free dye-based dye-sensitized so
Substituted dienes prepared from betulinic acid – Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters
Frydrych, Ivo,Urban, Milan,?arek, Jan,Benická, Sandra,D?ubák, Petr,Gurská, Soňa,Hajdúch, Marián,Kotulová, Jana,Li?ková, Barbora,Olejníková, Denisa,Pokorny, Jan
, (2021/07/28)
A set of new substituted dienes were synthesized from betulinic acid by its oxidation to 30-oxobetulinic acid followed by the Wittig reaction. Cytotoxicity of all compounds was tested in vitro in eight cancer cell lines and two noncancer fibroblasts. Almost all dienes were more cytotoxic than betulinic acid. Compounds 4.22, 4.30, 4.33, 4.39 had IC50 below 5 μmol/L; 4.22 and 4.39 were selected for studies of the mechanism of action. Cell cycle analysis revealed an increase in the number of apoptotic cells at 5 × IC50 concentration, where activation of irreversible changes leading to cell death can be expected. Both 4.22 and 4.39 led to the accumulation of cells in the G0/G1 phase with partial inhibition of DNA/RNA synthesis at 1 × IC50 and almost complete inhibition at 5 × IC50. Interestingly, compound 4.39 at 5 × IC50 caused the accumulation of cells in the S phase. Higher concentrations of tested drugs probably inhibit more off-targets than lower concentrations. Mechanisms disrupting cellular metabolism can induce the accumulation of cells in the S phase. Both compounds 4.22 and 4.39 trigger selective apoptosis in cancer cells via intrinsic pathway, which we have demonstrated by changes in the expression of the crucial apoptosis-related protein. Pharmacological parameters of derivative 4.22 were superior to 4.39, therefore 4.22 was the finally selected candidate for the development of anticancer drug.
