51165-05-0

Basic information

• Product Name: SUBSTANCE P (7-11)
• Synonyms: SUBSTANCE P (7-11);SUBSTANCE P FRAGMENT 7-11;PHE-PHE-GLY-LEU-MET-NH2;PENTA-SUBSTANCE P;FFGLM-NH2;H-PHE-PHE-GLY-LEU-MET-NH2;SUBSTANCE P FRAGMENT 7-11 ACETATE);L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2
• CAS NO: 51165-05-0
• Molecular Formula: C₃₁H₄₄N₆O₅S
• Molecular Weight: 612.78
• Product Categories: Peptide
• Mol File: 51165-05-0.mol

Chemical Properties

• Boiling Point: 1003.3°C at 760 mmHg
• Flash Point: 560.6°C
• Appearance: /
• Density: 1.207g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: -15°C
• PKA: 13.26±0.46(Predicted)
• CAS DataBase Reference: SUBSTANCE P (7-11)(CAS DataBase Reference)
• NIST Chemistry Reference: SUBSTANCE P (7-11)(51165-05-0)
• EPA Substance Registry System: SUBSTANCE P (7-11)(51165-05-0)

Safety Data

• Hazardous Substances Data: 51165-05-0(Hazardous Substances Data)

Usage

Uses

Used in Scientific Research:
Substance P (7-11) is used as a research tool for studying the mechanisms of the neuropeptide system and its involvement in various physiological and pathological processes. This fragment helps researchers understand the interactions with NK1 and NK2 receptors, which are associated with substance P, and their roles in pain perception, stress responses, and tissue repair.

InChI:InChI=1/C31H44N6O5S/c1-20(2)16-25(31(42)36-24(28(33)39)14-15-43-3)35-27(38)19-34-30(41)26(18-22-12-8-5-9-13-22)37-29(40)23(32)17-21-10-6-4-7-11-21/h4-13,20,23-26H,14-19,32H2,1-3H3,(H2,33,39)(H,34,41)(H,35,38)(H,36,42)(H,37,40)/t23-,24-,25-,26-/m0/s1

Upstream product

• 73148-99-9 N-t-Boc-Phe-Phe-Gly-Leu-Met-NH₂ 
• 66876-64-0 Boc-Phe-Phe-Gly-OMe 
• 82816-76-0 N-tert-butoxycarbonyl-L-phenylalanine-L-phenylalanine-glycine 
• 7625-57-2 methyl 2-((2S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)acetate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 2280-68-4 N-tert-butoxycarbonyl-L-leucyl-L-methioninamide 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 2131-00-2 leucyl-methionine amide hydrochloride 

Downstream Products

• 119372-42-8 pentadecanoyl-Phe-Phe-Gly-Leu-Met-NH₂ 
• 71890-54-5 (S)-4-Methyl-2-{2-[(S)-3-phenyl-2-((S)-3-phenyl-2-phenylacetylamino-propionylamino)-propionylamino]-acetylamino}-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide 
• 73149-12-9 Boc-Tyr-Phe-Phe-Gly-Leu-Met-NH₂ 
• 61123-13-5 pyroglutamyl-phenylalanyl-phenylalanine-glycyl-leucyl-methionine amide 
• 108744-20-3 C₄₉H₆₁N₁₁O₁₀S 
• 71890-55-6 (S)-2-[2-((S)-2-{(S)-2-[2-(4-Hydroxy-phenyl)-acetylamino]-3-phenyl-propionylamino}-3-phenyl-propionylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide 
• 119372-40-6 (S)-2-[2-((S)-2-{(S)-2-[2-(4-Fluoro-phenyl)-acetylamino]-3-phenyl-propionylamino}-3-phenyl-propionylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide 
• 119372-38-2 (S)-2-[2-((S)-2-{(S)-2-[2-(2-Hydroxy-phenyl)-acetylamino]-3-phenyl-propionylamino}-3-phenyl-propionylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide 
• 73149-11-8 (S)-2-[2-((S)-2-{(S)-2-[3-(4-Hydroxy-phenyl)-propionylamino]-3-phenyl-propionylamino}-3-phenyl-propionylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide 
• 119372-43-9 Boc-aminocaproyl-Phe-Phe-Gly-Leu-Met-NH₂ 
• 71890-50-1 Ac-Phe₂-Gly-Leu-Met-NH₂ 
• 88364-84-5 [(S)-3-((S)-2-{2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-acetylamino}-4-methyl-pentanoylamino)-3-carbamoyl-propyl]-dimethyl-sulfonium 
• 70328-33-5 Z-Gln-Phe-Phe-Gly-Leu-Met-NH₂ 
• 119372-41-7 Tyr-Phe-Phe-Gly-Leu-Met-NH₂ 

Relevant articles and documents

Method and composition for treating IgE-mediated allergies

The present invention relates to a method and preparations for reducing IgE antibodies to allergens in allergic subjects wherein substance P and an allergen or fragments of allergens or haptens acting as allergens are administered together to the allergic subjects. The method can be used to treat humans and animals including dogs, cats, horses and subhuman primates.