5129-72-6

Usage

Uses

Used in Pharmaceutical Production:
N-Ethylpropionamide is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and medications.
Used as a Solvent:
N-ETHYLPROPIONAMIDE serves as a solvent in various chemical processes, facilitating reactions and aiding in the production of different substances.
Used in Organic Synthesis:
N-Ethylpropionamide is utilized as an intermediate in organic synthesis, playing a crucial role in the formation of complex organic compounds.
Used as a Flavoring Agent:
It is employed in the food and beverage industry as a flavoring agent, enhancing the taste and aroma of various products.
Used in Fragrance Manufacturing:
N-Ethylpropionamide is also used in the production of fragrances, contributing to the creation of scents for perfumes, cosmetics, and other scented products.
Safety:
Despite its low acute toxicity and relative safety for use in various applications, it is essential to handle N-Ethylpropionamide with care and adhere to safety guidelines to ensure the well-being of individuals and the environment.

Upstream product

• 60-29-7 diethyl ether 
• 593-63-5 chloroacetylene 
• 109-89-7 diethylamine 
• 802294-64-0 propionic acid 
• 109-76-2 Trimethylenediamine 
• 96-22-0 pentan-3-one 
• 75-04-7 ethylamine 

Downstream Products

• 20193-20-8 ethylpropylamine 
• 470678-30-9 ethyl-propionyl-carbamic acid benzyl ester 
• 189807-21-4 2-trifluoromethyl-4-fluorobenzoyl chloride 
• 5371-52-8 2-hydroxytetrahydrofuran 
• 2213-81-2 2-chloro-5-(1,1-dimethylethyl)-1,3-dinitrobenzene 
• 470677-99-7 ethyl-(1-trimethylsilanyloxy-propyl)-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Carboxyl activation of 2-mercapto-4,6-dimethylpyrimidine through n-acyl-4,6-dimethylpyrimidine-2-thione: A chemical and spectrophotometric investigation

2-Mercapto-4,6-dimethylpyrimidine, as effective carboxyl activating group, has been successfully proved by converting it into respective acyl derivatives and the subsequent conversion to the amides and esters respectively using amines, amino alcohols and alcohols. The aminolysis and esterification were monitored chemically and spectrophotometrically. This paved way to establish that the above mercaptopyrimidine derivative is an efficient carboxyl activating group applicable in solid phase peptide synthesis.

Microwave-assisted efficient one-step synthesis of amides from ketones and benzoxazoles from (2-hydroxyaryl) ketones with acetohydroxamic acid using sulfuric acid as the catalyst

Efficient one-step method for the synthesis of amides directly from ketones and benzoxazoles from (2-hydroxyaryl) ketones by the reaction of acetohydroxamic acid using sulfuric acid as catalyst was described.

Multigram Preparation of 2-Alkylpyrimidines in the Vapor Phase from Carboxylic Acids and 1,3-Diaminopropane over a Dual Catalyst System

2-Alkylpyrimidines 2 were obtained from cofeeding a carboxylic acid such as pivalic acid (3a) or propionic acid (3b) and 1,3-diaminopropane (4) over first an alumina catalyst at 250-290 deg C and second a palladium dehydrogenation catalyst at 300-340 deg C to give 2 directly in 56-68percent overall yields.On the alumina bed, initial amidation of organic acid occurs to give the monoacyltrimethylenediamine 5, followed by ring closure to the tetrahydropyrimidine intermediate 6.An equilibrium between 5, 6, and water is established on the alumina bed, with an apparent equilibrium constant of 53 +/- 7 mol/kg at 290 deg C.The high temperature of the alumina bed shifts the equilibrium in favor of 6, which is directly dehydrogenated to 2 over the palladium catalyst.The method avoids the need to isolate and purify solid intermediates.The presence of low levels of sulfur acts as a strong palladium catalyst deactivator.Gradual decline of palladium catalyst activity was observed due to carbon buildup.No decline in alumina catalyst activity was observed.The continuous process allows for the preparation of multigram quantities of 2 with a laboratory-scale reactor.

Process for the preparation of formamides

Formamides e.g. diethylformamide are prepared by reacting a primary or secondary amine e.g. diethylamine or ammonia with (a) an alkyl formate or (b) carbon monoxide and an alkanol in the presence, as catalyst, of (i) a compound containing an amidine group or (ii) a Group V element-containing Lewis base and an epoxide. The Lewis base can be a trivalent nitrogen or phosphorus-containing compound. The amidine group which can be cyclic or acyclic can form part of a guanidine group.