5129-72-6

Basic information

• Product Name: N-ETHYLPROPIONAMIDE
• Synonyms: ethylpropionamide;N-Ethylpropanamide;Propionamide, N-ethyl-;N-PROPIONYLETHYLAMINE;N-ETHYLPROPIONAMIDE;N-ETHYLPROPIONAMIDE 99+%;N-Ethylpropionamide
• CAS NO: 5129-72-6
• Molecular Formula: C₅H₁₁NO
• Molecular Weight: 101.15
• Mol File: 5129-72-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 116 °C / 25mmHg
• Appearance: /
• Density: 0,91 g/cm3
• Refractive Index: 1.4340-1.4370
• CAS DataBase Reference: N-ETHYLPROPIONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ETHYLPROPIONAMIDE(5129-72-6)
• EPA Substance Registry System: N-ETHYLPROPIONAMIDE(5129-72-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 5129-72-6(Hazardous Substances Data)

Usage

General Description

N-Ethylpropionamide is a chemical compound with the molecular formula C6H13NO. It is a white, crystalline solid that is soluble in water and has a mild, characteristic odor. N-Ethylpropionamide is used in the production of pharmaceuticals, as a solvent and as an intermediate in organic synthesis. It is also used as a flavoring agent and in the manufacturing of fragrances. N-Ethylpropionamide has low acute toxicity and is considered to be relatively safe for use in various industrial applications. However, it is important to handle this compound with care and to follow safety guidelines when working with it.

Upstream product

• 60-29-7 diethyl ether 
• 593-63-5 chloroacetylene 
• 109-89-7 diethylamine 
• 802294-64-0 propionic acid 
• 109-76-2 Trimethylenediamine 
• 96-22-0 pentan-3-one 
• 75-04-7 ethylamine 

Downstream Products

• 470678-30-9 ethyl-propionyl-carbamic acid benzyl ester 
• 189807-21-4 2-trifluoromethyl-4-fluorobenzoyl chloride 
• 2213-81-2 2-chloro-5-(1,1-dimethylethyl)-1,3-dinitrobenzene 
• 5371-52-8 2-hydroxytetrahydrofuran 
• 470677-99-7 ethyl-(1-trimethylsilanyloxy-propyl)-carbamic acid benzyl ester 
• 20193-20-8 ethylpropylamine 

Relevant articles and documents

Carboxyl activation of 2-mercapto-4,6-dimethylpyrimidine through n-acyl-4,6-dimethylpyrimidine-2-thione: A chemical and spectrophotometric investigation

2-Mercapto-4,6-dimethylpyrimidine, as effective carboxyl activating group, has been successfully proved by converting it into respective acyl derivatives and the subsequent conversion to the amides and esters respectively using amines, amino alcohols and alcohols. The aminolysis and esterification were monitored chemically and spectrophotometrically. This paved way to establish that the above mercaptopyrimidine derivative is an efficient carboxyl activating group applicable in solid phase peptide synthesis.

Multigram Preparation of 2-Alkylpyrimidines in the Vapor Phase from Carboxylic Acids and 1,3-Diaminopropane over a Dual Catalyst System

2-Alkylpyrimidines 2 were obtained from cofeeding a carboxylic acid such as pivalic acid (3a) or propionic acid (3b) and 1,3-diaminopropane (4) over first an alumina catalyst at 250-290 deg C and second a palladium dehydrogenation catalyst at 300-340 deg C to give 2 directly in 56-68percent overall yields.On the alumina bed, initial amidation of organic acid occurs to give the monoacyltrimethylenediamine 5, followed by ring closure to the tetrahydropyrimidine intermediate 6.An equilibrium between 5, 6, and water is established on the alumina bed, with an apparent equilibrium constant of 53 +/- 7 mol/kg at 290 deg C.The high temperature of the alumina bed shifts the equilibrium in favor of 6, which is directly dehydrogenated to 2 over the palladium catalyst.The method avoids the need to isolate and purify solid intermediates.The presence of low levels of sulfur acts as a strong palladium catalyst deactivator.Gradual decline of palladium catalyst activity was observed due to carbon buildup.No decline in alumina catalyst activity was observed.The continuous process allows for the preparation of multigram quantities of 2 with a laboratory-scale reactor.