51344-12-8

Basic information

• Product Name: 2-(4-methoxyphenoxy)-N,N-dimethylethanamine
• Synonyms: 2-(4-methoxyphenoxy)-N,N-dimethylethanamine;2-(4-Methoxyphenoxy)-N,N-dimethylethylamine
• CAS NO: 51344-12-8
• Molecular Formula: C₁₁H₁₇NO₂
• Molecular Weight: 195
• Mol File: 51344-12-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 281℃
• Flash Point: 98℃
• Appearance: /
• Density: 1.005
• PKA: 8.55±0.28(Predicted)
• CAS DataBase Reference: 2-(4-methoxyphenoxy)-N,N-dimethylethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenoxy)-N,N-dimethylethanamine(51344-12-8)
• EPA Substance Registry System: 2-(4-methoxyphenoxy)-N,N-dimethylethanamine(51344-12-8)

Safety Data

• Hazardous Substances Data: 51344-12-8(Hazardous Substances Data)

Usage

General Description

2-(4-methoxyphenoxy)-N,N-dimethylethanamine, also known as Mexypropamine, is a synthetic stimulant drug that belongs to the amphetamine class. It is a psychoactive substance that acts as a releasing agent for dopamine and norepinephrine, leading to increased energy, euphoria, and heightened alertness. Mexypropamine is a potent and long-lasting compound with effects similar to other stimulant drugs, such as amphetamine and methamphetamine. It is often used recreationally for its stimulating and euphoric effects, but has also been studied for potential medical applications in the treatment of conditions such as attention deficit hyperactivity disorder (ADHD) and narcolepsy. However, Mexypropamine is a controlled substance in many countries and is often subject to legal restrictions due to its potential for misuse and abuse.

Upstream product

• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 150-76-5 4-methoxy-phenol 
• 20570-41-6 2-(N,N-dimethylamino)ethyl methyl carbonate 
• 71-36-3 butan-1-ol 
• 67-63-0 isopropyl alcohol 
• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 105-58-8 Diethyl carbonate 
• 1877-75-4 2-(4-methoxyphenoxy)acetic acid 
• 137325-67-8 N,N-dimethyl-2-(4'-methoxyphenoxy)ethanamide 
• 22921-76-2 1-(2-bromoethoxy)-4-methoxybenzene 
• 124-40-3 dimethyl amine 
• 42082-29-1 p-methoxyphenoxyacetyl chloride 

Downstream Products

• 2603-69-2 C₃₂H₅₄N₂O₄⁽²⁺⁾*2Br^(1-) 
• 100238-29-7 N,N-dimethyl 4-hydroxyphenyl-2-oxyethylamine 
• 137325-71-4 Ethyl-[2-(4-methoxy-phenoxy)-ethyl]-dimethyl-ammonium; iodide 

Relevant articles and documents

Microwave-Assisted Aminoalkylation of Phenols via Mustard Carbonate Analogues

microwave-assisted chlorine-free direct phenol substitution is presented, which is indicated as a key green chemistry research area for pharmaceuticals manufacturers. The reaction of -aminocarbonates (mustard carbonates) with several substituted phenols in the presence of a polar solvent (acetonitrile or butanol) led to the related aminoalkylated products via the anchimeric assistance of the nitrogen incorporated in the organic carbonate backbone. The aminoalkylation required short reaction time (7 min) and the related products were isolated in high yields (>90%) via quick liquid-liquid extraction or column chromatography depending on the solvent employed. Furthermore, microwave irradiation also promoted the one-pot aminoalkylation of phenol in excellent yield. In this approach a -aminoalcohol was reacted with phenol in the presence of diethyl carbonate, used for the in situ formation -aminocarbonate, key intermediate in the consequent anchimerically driven alkylation. The resulting product, namely N,N-dimethyl- 2-phenoxyethanamine, was isolated as pure in almost quantitative yield.

Discovery of novel quinoline-based estrogen receptor ligands using peptide interaction profiling

Traditional approaches to discovery of selective estrogen receptor modulators (SERMs) have relied on ER binding and cell-based estrogen response element-driven assays to identify compounds that are osteoprotective but nonproliferative in breast and uterin