51344-12-8

Usage

Uses

Used in Recreational Settings:
Mexypropamine is used recreationally for its stimulating and euphoric effects, providing users with a sense of increased energy and alertness.
Used in Medical Research:
In the medical field, Mexypropamine has been studied for its potential applications in the treatment of conditions such as attention deficit hyperactivity disorder (ADHD) and narcolepsy, due to its effects on neurotransmitter release and its ability to promote wakefulness.
Used in Pharmaceutical Development:
Mexypropamine's potent and long-lasting stimulant properties have made it a subject of interest for pharmaceutical research and development, with the aim of creating safer and more effective treatments for various medical conditions.
Used in Controlled Substances Regulation:
Due to its potential for misuse and abuse, Mexypropamine is a controlled substance in many countries, subject to legal restrictions to prevent illicit use and ensure that its distribution and consumption are monitored and regulated.
Note: The use of Mexypropamine in medical applications is speculative based on the provided materials, as it mentions that it has been studied for potential medical applications. However, it is important to clarify that the actual medical use of Mexypropamine would require further research, clinical trials, and regulatory approval.

Upstream product

• 22921-76-2 1-(2-bromoethoxy)-4-methoxybenzene 
• 124-40-3 dimethyl amine 
• 137325-67-8 N,N-dimethyl-2-(4'-methoxyphenoxy)ethanamide 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 150-76-5 4-methoxy-phenol 
• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 105-58-8 Diethyl carbonate 
• 20570-41-6 2-(N,N-dimethylamino)ethyl methyl carbonate 
• 71-36-3 butan-1-ol 
• 67-63-0 isopropyl alcohol 
• 42082-29-1 p-methoxyphenoxyacetyl chloride 
• 1877-75-4 2-(4-methoxyphenoxy)acetic acid 

Downstream Products

• 2603-69-2 C₃₂H₅₄N₂O₄⁽²⁺⁾*2Br^(1-) 
• 100238-29-7 N,N-dimethyl 4-hydroxyphenyl-2-oxyethylamine 
• 137325-71-4 Ethyl-[2-(4-methoxy-phenoxy)-ethyl]-dimethyl-ammonium; iodide 

Relevant academic research and scientific papers

Microwave-Assisted Aminoalkylation of Phenols via Mustard Carbonate Analogues

microwave-assisted chlorine-free direct phenol substitution is presented, which is indicated as a key green chemistry research area for pharmaceuticals manufacturers. The reaction of -aminocarbonates (mustard carbonates) with several substituted phenols in the presence of a polar solvent (acetonitrile or butanol) led to the related aminoalkylated products via the anchimeric assistance of the nitrogen incorporated in the organic carbonate backbone. The aminoalkylation required short reaction time (7 min) and the related products were isolated in high yields (>90%) via quick liquid-liquid extraction or column chromatography depending on the solvent employed. Furthermore, microwave irradiation also promoted the one-pot aminoalkylation of phenol in excellent yield. In this approach a -aminoalcohol was reacted with phenol in the presence of diethyl carbonate, used for the in situ formation -aminocarbonate, key intermediate in the consequent anchimerically driven alkylation. The resulting product, namely N,N-dimethyl- 2-phenoxyethanamine, was isolated as pure in almost quantitative yield.

Mustard Carbonate Analogues as Sustainable Reagents for the Aminoalkylation of Phenols

N,N-dialkyl ethylamine moiety can be found in numerous scaffolds of macromolecules, catalysts, and especially pharmaceuticals. Common synthetic procedures for its incorporation in a substrate relies on the use of a nitrogen mustard gas or on multistep syntheses featuring chlorine hazardous/toxic chemistry. Reported herein is a one-pot synthetic approach for the easy introduction of aminoalkyl chain into different phenolic substrates through dialkyl carbonate (β-aminocarbonate) chemistry. This new direct alcohol substitution avoids the use of chlorine chemistry, and it is efficient on numerous pharmacophore scaffolds with good to quantitative yield. The cytotoxicity via MTT of the β-aminocarbonate, key intermediate of this synthetic approach, was also evaluated and compared with its alcohol precursor.

Discovery of novel quinoline-based estrogen receptor ligands using peptide interaction profiling

Traditional approaches to discovery of selective estrogen receptor modulators (SERMs) have relied on ER binding and cell-based estrogen response element-driven assays to identify compounds that are osteoprotective but nonproliferative in breast and uterin