51344-14-0

Basic information

• Product Name: N,N-Dimethyl-2-(p-tolyloxy)ethanamine
• Synonyms: N,N-Dimethyl-2-(p-tolyloxy)ethanamine
• CAS NO: 51344-14-0
• Molecular Formula: C₁₁H₁₇NO
• Molecular Weight: 179.25878
• Mol File: 51344-14-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: N,N-Dimethyl-2-(p-tolyloxy)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Dimethyl-2-(p-tolyloxy)ethanamine(51344-14-0)
• EPA Substance Registry System: N,N-Dimethyl-2-(p-tolyloxy)ethanamine(51344-14-0)

Safety Data

• Hazardous Substances Data: 51344-14-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N,N-Dimethyl-2-(p-tolyloxy)ethanamine is used as a key intermediate for the synthesis of various pharmaceuticals, including anti-inflammatory drugs and antihistamines, due to its ability to contribute to the development of these medications' active ingredients.
Used in Agrochemical Production:
In the agrochemical industry, N,N-Dimethyl-2-(p-tolyloxy)ethanamine is utilized as a component in the production of pesticides and other related chemicals, highlighting its importance in creating effective agricultural solutions.
Used in Material Science:
DMBA is also used as a precursor in material science for the development of new materials and polymers, indicating its potential in advancing the field of material innovation and technology.

Upstream product

• 18800-34-5 1-bromo-2-(4'-methylphenoxy)ethane 
• 124-40-3 dimethyl amine 
• 1121-70-6 sodium 4-methylphenoxide 
• 107-99-3 2-(dimethylamino)ethyl chloride 
• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 624-31-7 4-tolyl iodide 
• 106-44-5 p-cresol 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 

Downstream Products

• 2401-54-9 C₃₂H₅₄N₂O₂⁽²⁺⁾*2Br^(1-) 
• 106-44-5 p-cresol 
• 122892-31-3 N-<4-<2-(dimethylamino)ethoxy>benzyl>-3,4-dimethoxybenzamide hydrochloride 
• 122898-67-3 itopride 
• 98766-39-3 (2-Chloro-benzyl)-dimethyl-(2-p-tolyloxy-ethyl)-ammonium; chloride 
• 98766-41-7 (4-Chloro-benzyl)-dimethyl-(2-p-tolyloxy-ethyl)-ammonium; chloride 
• 98766-29-1 Dimethyl-(4-nitro-benzyl)-(2-p-tolyloxy-ethyl)-ammonium; chloride 

Relevant articles and documents

Synthesis and characterization of herbicidal ionic liquids based on (4-chloro-2-methylphenoxy)acetate and phenoxyethylammonium

Ten ionic liquids containing the (4-chloro-2-methylphenoxy)acetate (MCPA) anion and domiphen derived phenoxyethylammonium cation were synthesized. The obtained compounds differed in terms of the substitution of the phenoxyethylammonium group in the ring (the presence of a methyl group in the meta or para positions and the presence of chlorine in the para position) as well as the length of the alkyl chain (from hexyl to tetradecyl). The basic physicochemical properties of the obtained ionic liquids (solubility and thermal stability) were characterized and their structures were confirmed. The herbicidal activity of the compounds was tested under greenhouse conditions using cornflower (Centaurea cyanus L.) as the test plant.

Preparation method of medicine of itopride hydrochloride for promoting gastrointestinal motility

The invention discloses a preparation method of medicine of itopride hydrochloride for promoting gastrointestinal motility. The method comprises the following steps that p-hydroxy methylbenzene is used as a raw material to take a reaction with dimethylaminoethyl chloride hydrochloride; then, 4-(2-dimethylamino oxethyl) benzyl bromide is synthesized through bromination; next, the 4-(2-dimethylamino oxethyl) benzyl bromide and 3,4-dimethoxybenzonitrile take a reaction to obtain a product of itopride under the solvent-free condition through copper trifluoromethanesulfonate catalysis. The preparation method has the advantages a bran-new synthesis route is provided; the itopride is synthesized through Ritter reaction under the solvent-free condition; the advantage of green and environment-friendly effects is realized; meanwhile, the used raw material resources are wide and sufficient; the price is low; the reaction conditions are mild.

Preparation method of 4-(2-dimethylaminoethoxy)benzylamine

The invention provides a preparation method of 4-(2-dimethylaminoethoxy)benzylamine. The preparation method comprises the following steps: dissolving 4-(2-dimethylaminoethoxy)benzyl bromide and urotropin in a solvent and reacting; after reacting, recycling the solvent; hydrolyzing a reaction product under an acidic condition; and adding an alkali and neutralizing to obtain the 4-(2-dimethylaminoethoxy)benzylamine. According to the preparation method provided by the invention, the raw materials have low prices and are easy to obtain; industrialization of the process is easy to realize; and the final product has high purity.

METHOD FOR SYNTHESIZING PHENOL USING METAL CATALYST

The present invention relates to a method for synthesizing phenol using a metal catalyst and, more specifically, to a method for preparing phenol, which is a product of cross-coupling reaction by performing reaction of aryl halide and 2-dimethylaminoethanol in the presence of a metal catalyst. According to the present invention, phenol, as a product of cross-coupling reaction by performing reaction of aryl halide and 2-dimethylaminoethanol in the presence of a metal catalyst, can be synthesized with high yield. Also, various phenols having substituents can be synthesized.COPYRIGHT KIPO 2017

Reaction of 1,2-difunctionalized ethanes with aryl iodides in copper-catalyzed cross-coupling: Application to synthesis of phenols

A series of 1,2-difunctionalized ethanes, such as ethylene glycol, 2-aminoethanol, 1,2-diaminoethane, 2-dimethylaminoethanol N',N'-dimethylethane-1,2-diamine, were investigated to test the reactivity with aryl iodides in the presence of copper catalysts. Under the reaction conditions, they produce the various Cheteroatom cross-coupled products. Interestingly, ethylene glycol and 2-dimethylaminoethanol afforded mainly the phenolic compounds while the others produced different cross-coupled products. Although ethylene glycol and 2-dimethylaminoethanol resulted in the same product, their behaviors in the reaction were quite different: ethylene glycol appears to mostly act as the ligand and 2-dimethylaminoethanol appears to serve as both the ligand and reactant. This finding led to a copper-catalyzed synthesis of phenols using either ethylene glycol or 2-dimethylaminoethanol, which can be applied to a variety of aryl iodides, providing an alternative synthetic route to phenols.

Steric effects in intramolecular [2+2] photocycloaddition of C=C double bonds to cyclohexenones

The effect of substituents on the mode of approach and the endo/exo ratio in intramolecular [2+2] photocycloaddition reactions were studied.