N,N-Dimethyl-2-(p-tolyloxy)ethanamine

Base Information

• Chemical Name: N,N-Dimethyl-2-(p-tolyloxy)ethanamine
• CAS No.: 51344-14-0
• Molecular Formula: C11H17NO
• Molecular Weight: 179.262
• Hs Code.: 2922290090
• DSSTox Substance ID: DTXSID60414104
• Nikkaji Number: J618.344A
• Wikidata: Q82222716
• Mol file: 51344-14-0.mol

Synonyms:N,N-Dimethyl-2-(p-tolyloxy)ethanamine;51344-14-0;N,N-dimethyl-2-(4-methylphenoxy)ethanamine;Ethanamine, N,N-dimethyl-2-(4-methylphenoxy)-;SCHEMBL91406;DTXSID60414104;BCA34414;MFCD06304626;AKOS002774315;DS-8976;N,N-dimethyl-2-(4-methylphenoxy)ethylamine;CS-0153047;C75405;N pound notN-Dimethyl-2-(p-tolyloxy)ethanamine;A871305

Chemical Property of N,N-Dimethyl-2-(p-tolyloxy)ethanamine

Chemical Property:

• PSA: 12.47000
• LogP: 1.93540
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 179.131014166
• Heavy Atom Count: 13
• Complexity: 128

Purity/Quality:

99% ^*data from raw suppliers

N,N-Dimethyl-2-(p-tolyloxy)ethanamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)OCCN(C)C

Technology Process of N,N-Dimethyl-2-(p-tolyloxy)ethanamine

There total 4 articles about N,N-Dimethyl-2-(p-tolyloxy)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

p-cresol (106-44-5) + (2-chloroethyl)dimethylamine hydrochloride (4584-46-7) → N,N-dimethyl-2-<4-methylphenoxy>-ethylamine (51344-14-0)

Guidance literature:

With triethylamine; potassium hydroxide; In di-isopropyl ether; N,N-dimethyl-formamide; at 80 ℃; for 2h; Reagent/catalyst;

Reference yield: 78.0%

sodium 4-methylphenoxide (1121-70-6) + 2-(dimethylamino)ethyl chloride (107-99-3) → N,N-dimethyl-2-<4-methylphenoxy>-ethylamine (51344-14-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 100 ℃; for 4h;

DOI:10.1016/S0040-4020(01)80336-7

Reference yield: 64.0%

2-(N,N-dimethylamino)ethanol (108-01-0) + 4-tolyl iodide (624-31-7) → p-cresol (106-44-5) + N,N-dimethyl-2-<4-methylphenoxy>-ethylamine (51344-14-0)

Guidance literature:

With potassium hydroxide; silver(l) oxide; In dimethyl sulfoxide; at 100 ℃; for 24h; Solvent;

upstream raw materials:

1-bromo-2-(4'-methylphenoxy)ethane

dimethyl amine

sodium 4-methylphenoxide

2-(dimethylamino)ethyl chloride

Downstream raw materials:

p-cresol

N-<4-<2-(dimethylamino)ethoxy>benzyl>-3,4-dimethoxybenzamide hydrochloride

itopride

C₃₂H₅₄N₂O₂⁽²⁺⁾*2Br^(1-)

Refernces

• 1、 -. "METHOD FOR SYNTHESIZING PHENOL USING METAL CATALYST". Paragraph 0046; 0047. . Retrieved 2017/10/26.
• 2、 -. "Preparation method of 4-(2-dimethylaminoethoxy)benzylamine". Paragraph 0030; 0031; 0032; 0033. . Retrieved 2017/07/19.