5157-62-0

Usage

Explanation

A heterocyclic compound is a cyclic compound that contains atoms of at least two different elements, in this case, nitrogen and oxygen.
3. Five-membered ring structure

Explanation

The compound has a ring structure consisting of five atoms, which are part of the oxadiazole group.
4. White to off-white solid

Explanation

The appearance of the compound is a white to off-white solid, which is a common form for many organic compounds.
5. Used in organic synthesis

Explanation

The compound is utilized as a reagent or building block in various organic synthesis reactions, which involve the formation of new chemical bonds.
6. Building block in pharmaceutical compounds

Explanation

It serves as a component in the development of pharmaceutical compounds, which can be used for various medical applications.
7. Potential applications in drug development, agrochemicals, and materials science

Explanation

The compound has potential uses in the development of new drugs, agrochemicals (chemicals used in agriculture), and materials science, which involves the study and development of novel materials with specific properties.
8. Antimicrobial properties

Explanation

The compound may have the ability to inhibit the growth of or destroy microorganisms, such as bacteria and fungi.
9. Anticancer properties

Explanation

It may possess the ability to inhibit or prevent the growth of cancer cells, making it a potential candidate for cancer treatment research.
10. Antidepressant properties

Explanation

The compound may have the potential to alleviate symptoms of depression, making it a subject of interest for researchers studying its therapeutic uses in the medical field.

Upstream product

• 613-92-3 N-hydroxybenzamidine 
• 122-51-0 orthoformic acid triethyl ester 
• 692-45-5 vinyl formate 
• 613-92-3 N-hydroxybenzenecarboximidamide 
• 90049-76-6 5-iodo-3-phenyl-[1,2,4]oxadiazole 
• 613-92-3 N-hydroxyl-benzamidine 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 4755-77-5 Ethyl oxalyl chloride 
• 37760-54-6 3-phenyl-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester 
• 100-47-0 benzonitrile 
• 149-73-5 trimethyl orthoformate 
• 1263279-50-0 5-bromo-3-phenyl-[1,2,4]oxadiazole 
• 880634-98-0 2-methyl-2H-1,2,3-triazol-4-yl(dinitro)(3-phenyl-1,2,4-oxadiazol-5-yl)methane 
• 530-50-7 1,1-Diphenylhydrazine 

Downstream Products

• 888-71-1 3,5-diphenyl-1,2,4-oxadiazole 
• 90049-83-5 3-(3-nitro-phenyl)-[1,2,4]oxadiazole 
• 16013-14-2 3-(4-nitrophenyl)-[1,2,4]oxadiazole 

Relevant academic research and scientific papers

Palladium-Catalyzed, Silver-Assisted Direct C-5–H Arylation of 3-Substituted 1,2,4-Oxadiazoles under Microwave Irradiation

A direct C-5–H arylation of 3-substituted 1,2,4-oxadiazoles with aryl iodides in the presence of a palladium catalyst and silver acetate is reported. This method provides a rapid, reliable way to obtain versatile 3,5-diaryl-1,2,4-oxadiazole derivatives, which are common moieties of many biologically active molecules. The synthetic applications of this novel method have been demonstrated in the concise syntheses of Ataluren and a potent RET inhibitor Yhhu251. (Figure presented.).

Iron(III) Chloride/l-Proline as an Efficient Catalyst for the Synthesis of 3-Substituted 1,2,4-Oxadiazoles from Amidoximes and Triethyl Orthoformate

A general, facile, and efficient method is presented for the synthesis of 3-substituted 1,2,4-oxadiazoles from amidoximes and triethyl orthoformate. The procedure employs an iron(III) chloride/l-proline catalytic system and the 3-substituted 1,2,4-oxadiaz

Some regularities of the synthesis of ethyl 3-aryl-1,2,4-oxadiazole-5-carboxylates

Features of amidoximes reactions with ethyl chlorooxalate in a wide range of solvents at the use of a number of bases were investigated. An efficient preparation method for ethyl 3-aryl-1,2,4-oxadiazole-5-carboxylates in acetonitrile in the presence of triethylamine was developed.

Cycloaddition of benzonitrile oxide to pyridazine, pyrimidine and pyrazine

Cycloaddition of benzonitrile oxide to pyridazine affords an isolable mono-cycloadduct. In cycloadditions to pyrimidine and pyrazine the primary mono-cycloadducts are labile intermediates which undergo further cycloaddition affording isolable bis- and tris-cycloadducts.

SYNTHESIS OF TRIAZOLES AND OXADIAZOLES FROM 2-ARYL-3-PHENYL-4-IMINO-5-CYANO-3,4-DIHYDROPYRIMIDINES

2-Aryl-3-phenyl-4-imino-5-cyano-3,4-dihydropyrimidines I were transformed to 1,2,4-triazoles II,IV and 1,2,4-oxadiazoles III by treatment with hydrazine, arylhydrazines or hydroxylamine in yields up to 90percent.