51671-72-8

Usage

Classification

Nonsteroidal anti-inflammatory drug (NSAID)
A drug class used to relieve pain and reduce inflammation

Common uses

Arthritis, menstrual discomfort

Chemical structure

Benzoic acid molecule with a carbonyl group attached to a 4-hydroxy-3-methylphenyl group
The specific arrangement of atoms and functional groups in the molecule

Mechanism of action

Inhibition of prostaglandin production
Prostaglandins are molecules involved in the inflammatory response

Administration

Oral medication, topical gel
The ways in which the drug can be taken

Enzyme blocking

Reduces pain and inflammation
By blocking enzymes responsible for producing prostaglandins

Side effects

Gastrointestinal irritation, increased risk of cardiovascular events
Potential negative effects of using the drug

Precautions

Use with caution, under the supervision of a healthcare professional
To minimize potential side effects and ensure safe usage

Upstream product

• 85-44-9 phthalic anhydride 
• 95-48-7 ortho-cresol 
• 7446-70-0 aluminium trichloride 
• 79-34-5 1,1,2,2-tetrachloroethane 
• 630-20-6 1,1,1,2-tetrachoroethane 
• 85-57-4 2-(4-hydroxy-benzoyl)-benzoic acid 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 596-27-0 o-cresolphthalein 
• 854-76-2 [3-(3'-methyl-4'-hydroxyphenyl)-3-(4''-hydroxyphenyl)phthalide] 

Downstream Products

• 51671-71-7 2-(3-methyl-4-methoxybenzoyl) benzoic acid 
• 1623008-15-0 4-(3-methyl-4-hydroxyphenyl)-2-(pentafluorophenyl)phthalazin-1(2H)-one 
• 860562-46-5 6'-methoxy-2,3'-carbonyl-di-benzoic acid 

Relevant academic research and scientific papers

Synthesis and characterization of highly fluorinated poly(phthalazinone ether)s based on AB-type monomers

Four different fluorinated methyl- and phenyl-substituted 4-(4-hydroxyphenyl)-2-(pentafluorophenyl)-phthalazin-1(2H)-ones, AB-type phthalazinone monomers, have been successfully synthesized by nucleophilic addition-elimination reactions of methyl- and phenyl-substituted 2-((4-hydroxy)benzoyl)benzoic acid with 1-(pentafluorophenyl)hydrazine. Under mild reaction conditions, the AB-type monomers underwent self-condensation polymerization reactions successfully and gave fluorinated poly(phthalazinone ether)s with high molecular weights. Detailed structural characterization of the AB-type monomers and fluorinated polymers was determined by 1H NMR, 19F NMR, FTIR, and GPC. The solubility, thermal properties, mechanical properties, water contact angles, and optical absorption of the polymers were evaluated. The polymers had high Tgs varying from 337 to 349 °C and decomposition temperatures (Td, 25 wt %) above 409 °C. Tough, flexible films were cast from THF and chloroform solutions. The films showed excellent tensile strengths ranging from 70 to 85 MPa with good hydrophobicities with water contact angles higher than 95.5 °C. The polymers had absorption edges below 340 nm and very low absorbance per cm at higher wavelengths 500-2500 nm. These results indicate that the polymers are promising as high performance materials, for example, membranes and hydrophobic materials.

3,3-Diarylphthalides. Part I. Friedlaender reaction of 3′-alkylphenolphthaleins

Friedlaender reaction was investigated, starting from 3′-alkyl-derivatives of phenolphthalein 1-3 (alkyl = Me, Et and i-Pr) and hydroxylamine in strongly alkaline medium. The process was found to give, after acidic hydrolysis of primarily formed anil-type semi-products, a mixture of two 2-aroylbenzoic acids (2-ABAs) in each case. Identification and quantification of 2-ABAs were carried out within RP-HPLC on ODS column. Based on quantitative results, migratory aptitude (MA) parameter values of ionized 4-hydroxy-3-alkylphenyl nuclei were calculated, taking an unsubstituted ionized 4-hydroxyphenyl ring as a standard.