51689-36-2Relevant articles and documents
Cyanodibenzo[1,4]dioxines: A new family of synthons for substituted dibenzo[1,4]dioxines
Eastmond, Geoffrey C.,Paprotny, Jerzy
, p. 479 - 480 (1999)
Cyanodibenzo[1,4]dioxines, previously unreported, are prepared quantitatively from catechols by nucleophilic fluorodisplacement from 2,3- and 3,4-difluorobenzonitriles, involving meta-fluorodisplacement, in DMF at 130 °C in the presence of potassium carbonate; the cyano-substituted dioxines can be transformed to other substituted dibenzo[1,4]dioxines.
CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF
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, (2019/01/10)
Small molecule calpain modulator compositions and pharmaceutical compositions can be prepared and used as therapeutic agents. Exemplary compositions include non-macrocyclic a-keto amide derivatives. The therarapeutic agents can be used for treating fibrot
Syntheses of dibenzodioxin derivatives via iron complexes, and further functionalizations via directed metallation
Cambie, Richard C.,Janssen, Sally J.,Rutledge, Peter S.,Woodgate, Paul D.
, p. 387 - 418 (2007/10/02)
Double nucleophilic aromatic substitution reactions between (cyclopentadienyl)(η6-1,2-dichlorobenzene)iron(1 +) salts and substituted 1,2-benzenediols have been carried out under mild conditions to prepare 6-dibenzodioxin>iron(1 +) complexes functionalized in the 1- or 2-position with an alkyl, aldehyde, carboxylic acid, methoxycarbonyl, carboxamide, or hydroxy group. 3-Methyl- and 4-methyl-(η6-1,2-dichlorobenzene)iron complexes were treated with substituted 1,2-benzenediols to effect functionalization of both aromatic rings of the heterocycle.The dibenzodioxin ligands were liberated routinely by irradiation with ultraviolet light.Directed deprotonation of the free functionalized dibenzodioxins with an alkyllithium reagent followed by quenching with a variety of electrophiles yielded further derivatives, including two new isoindolone systems.