51705-36-3

Upstream product

• 186581-53-3 diazomethane 
• 35388-57-9 (2S,3R)-(+)-piscidic acid 
• 154722-74-4 methyl 2-oxo-3-(4-hydroxyphenyl)propionate 
• 5544-60-5 4-(benzyloxy)benzyl bromide 
• 862252-61-7 methyl (4-hydroxyphenyl)pyruvate, enol form 
• 240405-26-9 dimethyl (Z)-(4-tert-butyldimethylsilyloxybenzyl)maleate 
• 240405-25-8 dimethyl (Z)-(4-hydroxybenzyl)maleate 
• 156-39-8 4-hydroxyphenylpiruvic acid 
• 240405-27-0 dimethyl (2S,3R)-3-(4-tert-butyldimethylsilyloxybenzyl)tartrate 
• 67-56-1 methanol 

Downstream Products

• 51643-34-6 4'-O-methyl-piscidic acid dimethyl ester 
• 60449-57-2 (2R:3S)-2-hydroxy-3-methoxy-2-(4-methoxy-benzyl)-succinic acid dimethyl ester 
• 35388-57-9 (2S,3R)-(+)-piscidic acid 

Relevant academic research and scientific papers

A Stereoselective Synthesis of (+)-Piscidic Acid and Cimicifugic Acid L

Alkylation of the lithium enolate of (2S,3S,5S,6S)-dimethoxy-2,3-dimethyl-1,4-dioxane-5,6-dithiocarboxylate using 4-benzyloxybenzyl bromide stereoselectively gave two new stereogenic centres with the carboxylate groups in a cis relationship. Hydrolytic de

Total synthesis of (+)-(2S,3R)-piscidic acid via catalytic asymmetric dihydroxylation of a trisubstituted olefin

(+)-(2S,3R)-Piscidic acid was efficiently synthesized with high optical purity (90% e.e.) via Sharpless catalytic asymmetric dihydroxylation of a trisubstituted olefin in only 6 steps from commercially available 4-hydroxyphenylpyruvic acid as the starting

Total syntheses of all four stereoisomers of piscidic acid via catalytic asymmetric dihydroxylation of (Z)- and (E)-trisubstituted olefins

All four stereoisomers of (2S, 3R)-(+)-piscidic acid were synthesized with high optical purity via Sharpless catalytic asymmetric dihydroxylation of (Z)- and (E)-trisubstituted olefins in 6 steps from (4-hydroxyphenyl)pyruvic acid. The Wittig reaction of