862252-61-7Relevant academic research and scientific papers
Furanone compound and preparation method and application thereof
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, (2020/07/13)
The invention discloses a furanone compound and a preparation method and application thereof. P-hydroxybenzaldehyde is used as a raw material, condensed with hydantoin and then subjected to alkaline hydrolysis and esterification to obtain a p-hydroxyphenylpyruvate intermediate; p-hydroxy benzaldehyde and halogenated isopentene are subjected to alkylation, and then benzyl protection is performed toobtain a benzaldehyde derivative intermediate; a benzaldehyde derivative intermediate and a phenylpyruvate intermediate are subjected to aldol condensation and intramolecular esterification under thecatalysis of a condensing agent to synthesize novel furanone compounds BL5 and BL10. The furanone derivative has H1N1 virus inhibition activity, and can be used for preparing medicines for treating H1N1 virus infection.
Total syntheses of all four stereoisomers of piscidic acid via catalytic asymmetric dihydroxylation of (Z)- and (E)-trisubstituted olefins
Toshima, Hiroaki,Saito, Masatoshi,Yoshihara, Teruhiko
, p. 1934 - 1941 (2007/10/03)
All four stereoisomers of (2S, 3R)-(+)-piscidic acid were synthesized with high optical purity via Sharpless catalytic asymmetric dihydroxylation of (Z)- and (E)-trisubstituted olefins in 6 steps from (4-hydroxyphenyl)pyruvic acid. The Wittig reaction of
