5173-05-7

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(1,1':2',1''-Terbenzen-4-yl)ethanone is utilized as a starting material for the synthesis of a variety of organic compounds and pharmaceuticals. Its structural properties and reactivity make it a valuable component in the development of new drugs and medications.
Used in Antihistamine Production:
In the pharmaceutical industry, 1-(1,1':2',1''-Terbenzen-4-yl)ethanone serves as a key intermediate in the production of antihistamine drugs. These drugs are essential for the treatment of allergies and allergic reactions, providing relief to patients suffering from these conditions.
Used in Organic Chemistry Research:
Due to its versatile reactivity and structural properties, 1-(1,1':2',1''-Terbenzen-4-yl)ethanone is also employed in organic chemistry research. It is a valuable building block for creating more complex molecules and compounds, contributing to the advancement of chemical knowledge and innovation.

Upstream product

• 69497-83-2 4-acetylphenyl mesylate 
• 4688-76-0 2-Biphenylboronic acid 
• 914675-52-8 2‐{[1,1'‐biphenyl]‐2‐yl}‐4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolane 
• 13329-40-3 4-Iodoacetophenone 
• 109613-00-5 4-acetophenyl triflate 
• 99-90-1 para-bromoacetophenone 
• 98-80-6 phenylboronic acid 
• 694-80-4 2-bromo-1-chlorobenzene 
• 7446-70-0 aluminium trichloride 
• 84-15-1 o-terphenyl 
• 107-06-2 1,2-dichloro-ethane 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 98-95-3 nitrobenzene 

Downstream Products

• 5173-11-5 4-ethyl-[1,1';2',1'']terphenyl 
• 5933-56-2 4-(o-terphenyl-4-yl-acetyl)-morpholine 

Relevant academic research and scientific papers

PALLADIUM CATALYST AND PROCESS FOR PRODUCTION OF BISARYL COMPOUND USING SAME

Disclosed are: a novel palladium catalyst which does not undergo leakage, can be recycled, does not require the use of any phosphorus-containing ligand, and has a high catalytic activity; and a process for producing a novel bisaryl compound using the palladium catalyst. In the production of a bisaryl compound by reacting an aromatic halide with an aromatic boronic acid in the presence of a palladium catalyst and a base, the palladium catalyst comprises a dendrimer containing a silica particle as a core and a palladium compound dissolved in an ionic liquid and supported on the dendrimer.

A highly sustainable and active catalyst for Suzuki-Miyaura reaction: Palladium-supported ionic liquid catalyst (SILC) coated with polymer

With the aid of an ionic liquid, palladium acetate was immobilized in the pores of silica gel, which was coated with polyethylene terephthalate. The heterogeneous catalyst was effective for Suzuki-Miyaura reactions of ortho-substituted aryl bromides, aryl triflates, and arylboronic acids in aqueous ethanol at room temperature, and could be re-used up to ten times. Georg Thieme Verlag Stuttgart · New York.

Immobilization of Pd on nanosilica dendrimer as SILC: Highly active and sustainable cluster catalyst for suzuki-miyaura reaction

Palladium acetate was noncovalently immobilized as a supported ionic liquid catalyst (SILC) in a nanosilica dendrimer, PAMDMAM, with the aid of an ionic liquid to form a cluster catalyst of palladium nanoparticles. The pseudo-homogeneous heterogenized catalyst, Pd-nanoPAMDMAM-SILC, was effective for Suzuki-Miyaura reactions of ortho-substituted aryl bromides or aryl triflates without a ligand in 50% aqueous ethanol in air at room temperature. The catalyst could be re-used up to five times in 93% average yield after simple centrifugation. TON reached 176,000. Georg Thieme Verlag Stuttgart.

Platinum-catalysed diborylation of arynes: Synthesis and reaction of 1,2-diborylarenes

Arynes are found to be facilely inserted into bis(pinacolato)diboron by using a platinum-isocyanide catalyst, affording diverse 1,2-diborylarenes, which can be converted into o-terphenyls via Suzuki-Miyaura coupling reaction.

A general palladium-catalyzed Suzuki-Miyaura coupling of aryl mesylates

(Chemical Equation Presented) Catalyze this! The first palladium-catalyzed Suzuki-Miyaura coupling of unactivated aryl mesylates is reported, with not only arylboronic acids, but also other organoboron nucleophiles (see picture; Z=B(OH)2, BF3K, BPin). The reaction conditions are compatible with various common functional groups (R1=alkyl, OMe, CHO, CO, CN, CO2R′, heteroaryl).

A practical and general synthesis of unsymmetrical terphenyls

(Chemical Equation Presented) A synthetic procedure was developed that enables sequential chemoselective Suzuki-Miyaura cross-coupling of chlorobromobenzene with arylboronic acids. The first coupling is achieved at room temperature using a ligandless palladium catalyst. The chlorobiaryl product can then be subjected directly to the second coupling, facilitated by the SPhos ligand. Using this methodology, parallel synthesis of 32 unsymmetrical o-, m-, and p-terphenyl compounds was accomplished in good to excellent overall yields.

Photopolymerization initiators

Ethylenically unsaturated monomers in the presence of a novel aromatic oligomeric compound or polymer having a polyhaloacetyl moiety attached thereto are polymerized upon exposure to a source of radiation.