51776-97-7

Usage

Chemical class

Quinolone antibiotic

Structure

Quinoline ring with a carboxylic acid and a trifluoromethyl group attached

Antibacterial activity

Active against a wide range of Gram-negative and Gram-positive bacteria

Trifluoromethyl group

Contributes to potency and broad spectrum of activity

Pharmaceutical potential

Significant potential in the development of antibiotics

Clinical use

Important component of many antibiotics used in clinical practice

InChI:InChI=1/C11H6F3NO3/c12-11(13,14)5-1-2-6-8(3-5)15-4-7(9(6)16)10(17)18/h1-4H,(H,15,16)(H,17,18)

Upstream product

• 79-00-5 1,1,2-trichloroethane 
• 598-39-0 1,1-difluoro-2-iodoethane 
• 74-85-1 ethene 
• 78-93-3 butanone 
• 7664-39-3 hydrogen fluoride 
• 74-84-0 ethane 
• 598-73-2 1-bromo-1,2,2-trifluoroethene 
• 76-13-1 1,1,2-Trichloro-1,2,2-trifluoroethane 
• 75-37-6 1,1-difluoroethane 
• 338-65-8 1-chloro-2,2-difluoroethane 
• 79-38-9 Chlorotrifluoroethylene 
• 540-59-0 1,2-Dichloroethylene 
• 75-02-5 1-fluoroethylene 
• 359-11-5 1,1,2-trifluoroethylene 

Relevant academic research and scientific papers

FLUOROETHANE PRODUCTION METHOD AND FLUOROOLEFIN PRODUCTION METHOD

The production method according to the present disclosure comprises obtaining a product comprising a fluoroethane from a fluoroethylene by a reaction in the presence of at least one catalyst. The reaction is performed in two or more reaction zones. Each reaction zone comprises a catalyst, and the fluoroethylene is supplied to each reaction zone to perform the reaction.

PRODUCTION METHOD FOR FLUORO-ETHANE AND PRODUCTION METHOD FOR FLUORO-OLEFIN

The production method according to the present disclosure comprises obtaining a product containing the fluoroethane from a fluoroethylene by a reaction in the presence of catalysts. Each catalyst is formed by supporting a noble metal on a carrier. A reactor for performing the reaction is filled with a catalyst having a noble metal concentration of C1 mass % based on the entire catalyst and a catalyst having a noble metal concentration of C2 mass % based on the entire catalyst to form an upstream portion and a downstream portion, respectively; and C1C2. The reaction is performed by bringing the fluoroethylene represented by formula (3) and hydrogen gas into contact with the upstream portion and the downstream portion in this order.

METHOD FOR PRODUCING 1,1,2-TRIFLUOROETHANE (HFC-143)

The present disclosure provides a method for producing HFC-143 that is not expensive, and that is more efficient than conventional methods. Specifically, the present disclosure provides a method for producing 1,1,2-trifluoroethane (HFC-143) that includes contacting at least one chlorine-containing compound selected from the group consisting of 1,1,2-trichloroethane (HCC-140), 1,2-dichloro-1-fluoroethane (HCFC-141), 1,1-dichloro-2-fluoroethane (HCFC-141a), (E,Z)-1,2-dichloroethylene (HCO-1130 (E,Z)), and (E,Z)-1-chloro-2-fluoroethylene (HCFO-1131 (E,Z)) with hydrogen fluoride to perform one or more fluorination reactions, thereby obtaining a reaction gas containing HFC-143, hydrogen chloride, and hydrogen fluoride.

METHOD FOR PRODUCING 1,1,2-TRIFLUOROETHANE (HFC-143)

The present disclosure provides a method for producing HFC-143 at low cost and more efficiently than when using conventional methods. Specifically, the present disclosure provides a method for producing 1,1,2-trifluoroethane (HFC-143), comprising performing one or more fluorination reactions by bringing at least one chlorine-containing compound selected from the group consisting of 2-chloro-1,1-difluoroethane (HCFC-142) and 1-chloro-1,2-difluoroethane (HCFC-142a) into contact with hydrogen fluoride to obtain a reaction gas containing HFC-143, hydrogen chloride, and hydrogen fluoride.

Method for synthesizing 1,2-difluoroethane and 1,1,2-trifluoroethane

The invention relates to a method for synthesizing 1,2-difluoroethane and 1,1,2-trifluoroethane, belonging to the field of organic chemical synthesis. The method for synthesizing 1,2-difluoroethane and 1,1,2-trifluoroethane is characterized in that ethylene (with a molecular formula of CH2=CH2) and chlorine (with a molecular formula of Cl2) are heated under the action of a catalyst to generate a mixture of 1,2-dichloroethane and 1,1,2-trichloroethane, and the mixture and hydrogen fluoride (with a molecular formula HF) are heated under the action of a fluorination catalyst to generate 1,2-difluoroethane and 1,1,2-trifluoroethane. According to the method, raw materials are low in process and convenient to obtain; product separation and purification are simple; industrial production is easy;and industrial three-waste generation amount is low.

METHOD FOR PRODUCING 1-CHLORO-1,2-DIFLUOROETHYLENE

The present invention provides a method for efficiently producing 1-chloro-1,2-difluoroethylene at low cost. Specifically, the present invention provides a method for producing 1-chloro-1,2-difluoroethylene, including the step of dehydrohalogenating chlorofluoroethane represented by formula (1) CFClX1—CHFX2 wherein X1 and X2 are different from each other and represent H, F, or Cl; and either X1 or X2 is H.

Gas-phase fluorination of fluoroethanes with elemental fluorine

Scientific basis for industrial gas-phase fluorination of fluoroethanes with elemental fluorine allowing production of higher-fluorinated fluoroethanes from lower-fluorinated compounds is developed. 2001 MAIK "Nauka/Interperiodica".

vic-difluorination of fluoroalkenes with xenon difiuoride: The effect of fluorine substituents on the reaction of alkenes with xenon difluoride

vic-Difluorination proceeds by the reaction of fluoroalkenes with xenon difluoride to afford the corresponding fluorinated compounds. From the reaction with polyfluoroalkenes, the products are obtained in high to excellent yields. In this reaction, the fluorine atom substituent of alkene stabilizes the cation intermediate and suppresses side-reactions such as rearrangement.

FLUORINATION OF HYDROCARBONS BY THE HIGHER FLUORIDES OF COBALT, MANGANESE, AND CERIUM

The fundamental possibility of producing partly fluorinated methanes, ethane, and propanes on an industrial scale was demonstrated with the higher fluorides of variable-valence metals as fluorinating agents.

DESORPTION OF REACTION PRODUCTS IN FLUORINATION OF ETHYLENE WITH COBALT TRIFLUORIDE

Some macrokinetic relationships of ethylene fluorination with cobalt trifluoride have been investigated.Dependences of the degree of ethylene conversion on time of contact and temperature in reactors of batch and continuous operation have been studied.