519141-18-5

Usage

General Description

2,5-Piperazinedione,3-methoxy-1,3,4-trimethyl-(9CI) is a chemical compound with the molecular formula C9H16N2O3. It belongs to the class of piperazinediones and is characterized by the presence of a piperazine ring with a methoxy group attached at position 3, as well as three methyl groups at positions 1, 3, and 4 of the piperazine ring. 2,5-Piperazinedione,3-methoxy-1,3,4-trimethyl-(9CI) is used in organic synthesis and pharmaceutical research, and it may have potential applications in the development of drugs and other bioactive compounds. However, further research is needed to fully understand its properties and potential uses.

Upstream product

• 67-56-1 methanol 
• 519141-24-3 3-carboxyl-1,3,4-trimethylpiperazine-2,5-dione 
• 519141-10-7 3-benzyloxycarbonyl-1,3-dimethylpiperazine-2,5-dione 
• 519141-03-8 1-methyl-3-benzyloxycarbonylpiperazine-2,5-dione 
• 865879-17-0 benzyl N-[N-t-butoxycarbonylsarcosyl]-2-benzyloxycarbonylglycinate 
• 519141-14-1 3-benzyloxycarbonyl-1,3,4-trimethylpiperazine-2,5-dione 
• 519141-04-9 3-benzyloxycarbonyl-1,4-dimethylpiperazine-2,5-dione 
• 865879-16-9 ethyl N-[N-benzyloxycarbonylsarcosyl]-2-ethoxycarbonylsarcosinate 
• 865879-15-8 3-(ethoxycarbonyl)-1,4-dimethylpiperazine-2,5-dione 

Downstream Products

• 198877-45-1 1,4-dimethyl-3-methylenepiperazine-2,5-dione 

Relevant academic research and scientific papers

The synthetic versatility of alkoxycarbonyl- and hydroxymethyl-piperazine- 2,5-diones

Alkoxycarbonylpiperazine-2,5-diones are versatile precursors for the α-functionalisation of piperazine-2,5-diones. The alkoxycarbonyl group activates the α-carbon position to alkylation reactions and this provides a mild and selective method for the extension of the carbon framework of piperazine-2,5-diones. In addition, the alkoxycarbonyl group can be converted to the carboxy group, which in turn can be 'deleted' or manipulated for the installation of carbon and/or heteroatom substituents where desired, the latter via N-acyliminium chemistry. We also demonstrate that hydroxymethylpiperazine-2, 5-diones complement carboxypiperazinediones as precursors for the generation of N-acyliminium ions.

Multi-purpose functionality for the structural elaboration of the piperazine-2,5-dione motif

Mild methods for controlled C- and N-alkylation of 3-benzyloxycarbonylpiperazine-2,5-diones are reported. The benzyloxylcarbonyl substituent can also serve as latent functionality for N-acyliminium ion formation and subsequent trapping enables installation of new carbon and/or heteroatom substituents.