51930-77-9Relevant academic research and scientific papers
ION CHANNEL MODULATORS
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Paragraph 0447; 0448, (2021/06/11)
The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.
SELECTIVE FLUORESCENT PROBE FOR ALDEHYDE DEHYDROGENASE
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, (2020/07/14)
High aldehyde dehydrogenase 1A1 (ALDH1A1) activity has emerged as a reliable marker for the identification of both normal and cancer stem cells. Herein, is presented AlDeSense, a turn-on green fluorescent probe for aldehyde dehydrogenase 1A1 (ALDH1A1) and Ctrl-AlDeSense, a matching non-responsive reagent. AlDeSense exhibits a 20-fold fluorescent enhancement when treated with ALDH1A1. Through the application of surface marker antibody staining, tumorsphere assays, and assessment of tumorigenicity, the disclosed results show that cells exhibiting high AlDeSense signal intensity have properties of cancer stem cells. Herein, is also reported the development of a red congener, red-AlDeSense. Importantly, red-AlDeSense represents one of only a few examples of a turn-on sensor in the red region using the d-PeT quenching mechanism.
Modulators of methyl modifying enzymes, compositions and uses thereof
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Page/Page column 97; 98; 224; 225, (2015/12/26)
Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
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Paragraph 00158; 00159, (2013/06/05)
Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein
