52085-92-4

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Dihydro-5-fluoro-1H-inden-1-ol is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs. Its fluorine atom can enhance the pharmacokinetic and pharmacodynamic properties of the resulting compounds, making it a key component in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2,3-dihydro-5-fluoro-1H-inden-1-ol is used as an intermediate in the synthesis of agrochemicals, potentially leading to the creation of new pesticides or other agricultural chemicals that can improve crop protection and yield.
Used in Organic Chemistry Research:
2,3-Dihydro-5-fluoro-1H-inden-1-ol serves as a research reagent in organic chemistry, facilitating the exploration of new synthetic pathways and the discovery of novel chemical reactions, thereby expanding the scope of organic synthesis.
Used in Biochemical Studies:
As a research reagent in biochemical studies, 2,3-dihydro-5-fluoro-1H-inden-1-ol aids in understanding the interactions between small molecules and biological systems, which is crucial for the development of new bioactive compounds and the study of biological mechanisms.

Upstream product

• 700-84-5 5-fluoro-1-indanone 
• 462-06-6 fluorobenzene 
• 347-93-3 3-chloro-4'-fluoropropiophenone 

Downstream Products

• 58485-67-9 1-chloro-5-fluoroindane 
• 1075-11-2 6-fluoroisoquinoline 
• 915030-25-0 1-cyano-5-fluoroindane 
• 628732-48-9 5-fluoro-indan-1-carboxylic acid 
• 1426653-99-7 3-amino-4-fluoro-N-((1R,2S)-5-fluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl)benzamide 
• 939760-59-5 C₉H₇FO 
• 52031-15-9 5-fluoro-1H-indene 

Relevant academic research and scientific papers

Synthesis of Indole-Dihydroisoquinoline Sulfonyl Ureas via Three-Component Reactions

Isoquinolines activated with sulfamoyl chlorides were reacted with indoles in a 3-component reaction to generate a library of dihydroisoquinoline derivatives. Using a differential protecting group strategy, products could be further derivatised. Synthesis of isoquinoline starting materials using several different methods is also described.

Umpolung of protons from H2O: A metal-free chemoselective reduction of carbonyl compounds: Via B2pin2/H2O systems

H2O is routinely described as a proton donor, however, in the presence of diboron compounds, the umpolung reaction of H2O under metal-free conditions was successfully developed, which could afford hydride species, leading to a highly efficient and chemoselective reduction of CO bonds. This strategy exhibits excellent chemoselectivities toward carbonyl groups in the presence of ester, olefin, halogen, thioether, sulfonyl, cyano as well as heteroaromatic groups.

HISTONE DEMETHYLASE INHIBITORS

Provided herein are substituted pyrazolylpyridine, pyrazolylpyridazine, and pyrazolylpyrimidine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

COMPOUNDS AND COMPOSITIONS AS PDGFR KINASE INHIBITORS

The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase

SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS

Compounds of Formula (I): or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1 receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.

ORGANIC COMPOUNDS

The present invention provides a compound of formula I: said compound is inhibitor of aldosterone synthase (CYP11B2), and/or 11beta-hydroxylase (CYP11B1), and/or aromatase, and thus can be employed for the treatment of a disorder or disease mediated by al

SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS

Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.

2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)

The use of a compound of formula (I): for the manufacture of a medicament for the treatment of conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1, also known as TRPV1).

Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/- indanes and structurally modified derivatives: Potent and selective inhibitors of aldosterone synthase

Elevated aldosterone levels are key effectors for the development and progression of congestive heart failure and myocardial fibrosis. Recently, we proposed inhibition of aldosterone synthase (CYP11B2) as an innovative strategy for the treatment of these

Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: Potent inhibitors of aldosterone synthase

Elevated plasma aldosterone levels play a detrimental role in certain forms of congestive heart failure and myocardial fibrosis. We proposed aldosterone synthase (CYP11B2) as a novel target for the treatment of these diseases. In this study, the synthesis