5212-67-9

Usage

InChI:InChI=1/C8H14O2/c1-7(2)5-3-4-6-8(9)10/h1,3-6H2,2H3,(H,9,10)

Upstream product

• 6887-97-4 6-Methylhept-6-enenitrile 
• 5212-66-8 2-(Bromomethyl)-2-methylcyclohexanone 
• 13756-93-9 2-methyl-<<<(4-methylphenyl)sulfonyl>oxy>methyl>cyclohexanone 
• 166533-72-8 ethyl 6-methyl-6-heptenoate 
• 7228-12-8 5-Methylhex-5-enyl toluene-p-sulfonate 
• 3128-07-2 6-oxoheptanoic acid 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 2067-33-6 5-bromopentanoic acid 
• 14660-52-7 ethyl 5-bromovalerate 
• 3859-30-1 1-(prop-1-en-2-yl)cyclopentan-1-ol 
• 120-92-3 cyclopentanone 
• 64-18-6 formic acid 
• 4049-81-4 2-methyl-1,5-hexadiene 

Downstream Products

• 1373273-38-1 (S)-3-(6-methylhept-6-enoyl)-4-phenyloxazolidin-2-one 
• 1373273-39-2 (2'S,4S)-3-(2,6-dimethylhept-6-enoyl)-4-phenyloxazolidin-2-one 
• 184867-90-1 (R)-1-Furan-2-yl-6-methyl-2-trityloxymethyl-hept-6-en-1-ol 
• 184867-89-8 (S)-1-Furan-2-yl-3-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-2-(4-methyl-pent-4-enyl)-propane-1,3-dione 
• 184867-88-7 (+)-N-(1-oxo-6-methylhept-6-ene)-2-methyl-3-phenyl-4-oxazolidin-5-one 

Relevant academic research and scientific papers

Pd-Catalyzed Highly Chemo- And Regioselective Hydrocarboxylation of Terminal Alkyl Olefins with Formic Acid

An efficient Pd-catalyzed hydrocarboxylation of alkenes with HCOOH is described. A wide variety of linear carboxylic acids bearing various functional groups can be obtained with excellent chemo- and regioselectivities under mild reaction conditions. The reaction process is operationally simple and requires no handling of toxic CO.

Synthetic method of terminal carboxylic acid

The invention discloses a synthetic method of a terminal carboxylic acid. The synthetic method is characterized by comprising the steps of adding an olefin represented by a formula (3) shown in the description, formic acid, acetic anhydride, Pd(OAc)2 and a monophosphorus ligand TFPP into an organic solvent in a proportion, carrying out hydrogen carbonylation reaction on the olefin represented by the formula (3) shown in the description, formic acid and acetic anhydride at 80-90 DEG C for 48h-72h under the catalysis of the metal palladium salt Pd(OAc)2 and the monophosphorus ligand TFPP so as to obtain the terminal carboxylic acid represented by a formula shown in the description, and separating a target product, namely the terminal carboxylic acid after the reaction is finished, wherein olefin represented by the formula (3) is selected from cycloolefins, or linear olefins of which the R1 is electron donating groups. By virtue of the method disclosed by the invention, corresponding terminal carboxylic acid and a derivative thereof can be prepared through the reaction under mild conditions of low temperature and no high pressure; and the steps of the synthetic method are simple and convenient, the operation is convenient, the yield is high, the energy source can be greatly saved, and the synthetic efficiency can be greatly improved.

Volatile amphibian pheromones: Macrolides from mantellid frogs from madagascar

Amphibians like water, but do they also notice volatile compounds in the air? Yes, they do. Macrolides, such as phoracantholide-J (see picture; upper right structure) or the newly discovered natural product gephyromantolide-A (left structure), are used for communication by mantelline frogs from Madagascar. Copyright

Total synthesis and selective activity of a new class of conformationally restrained epothilones

Stereoselective total syntheses of two novel conformationally restrained epothilone analogues are described. Evans asymmetric alkylation, Brown allylation, and a diastereoselective aldol reaction served as the key steps in the stereoselective synthesis of

CONFORMATIONALLY RESTRAINED EPOTHILONE ANALOGUES AS ANTI-LEUKEMIC AGENTS

A method for synthesizing anti-leukemic epothilone analogues includes rigidifying a region between the macrolactone ring and the aromatic side-chain. The anti-leukemic compositions are non-naturally occurring epothilone analogue that are rigidified between the macrolactone ring and the aromatic side-chain.

EPOTHILONE ANALOGUES

Epothilone analogues include a molecular scaffold which holds at least one segment of epothilone in a predetermined orientation and which rigidities a region between the macrolactone ring and the aromatic side-chain.

Taxane diterpenes 1. Control of relative and absolute stereochemistry in intramolecular pyrylium ylide-alkene cyclizations for the synthesis of taxol precursors

Intramolecular pyrylium ylide-alkene cyclizations provide control of the absolute stereochemistry at the crucial C-19 angular methyl group, and leads to bicyclo[5.4.03,8]undecenones that contain the structral elements of the B/C rings of the taxanes.

New strategy for the synthesis of the taxane diterpenes: Formation of the BC-rings of taxol via a [5+2]-pyrylium ylide-alkene cyclization, ring expansion strategy

The BC-rings of taxol can be synthesized using an intramolecular [5+2]- pyrylium ylide-alkene cyclization, followed by gem-methylcyclopropanation and reductive cleavage of the internal cyclopropane bond.