52183-58-1Relevant articles and documents
Synthesis of Disubstituted Alkanes and Piperazines as Potential Anthelmintics
Abuzar, Syed,Sharma, Satyavan
, p. 73 - 76 (2007/10/02)
A number of 1,2- and 1,3-di(4-substituted phenyl-thio/sulphono)alkanes (3-18) and 1,4-disubstituted piperazines (19-28) have been synthesized starting from 4-acetamidothiophenol (1) and piperazine, respectively.None of the compounds shows any noteworthy anthelmintic activity except 11 and 13 which eliminate 100percent of A. ceylanilum and H. nana worms from hamsters and rats respectively at a single oral dose of 250 mg/kg.