52224-89-2

Basic information

• Product Name: Benzene, (1-methoxyethyl)-, (R)-
• CAS NO: 52224-89-2
• Molecular Formula: C9H12O
• Molecular Weight: 136.194
• Mol File: 52224-89-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzene, (1-methoxyethyl)-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, (1-methoxyethyl)-, (R)-(52224-89-2)
• EPA Substance Registry System: Benzene, (1-methoxyethyl)-, (R)-(52224-89-2)

Safety Data

• Hazardous Substances Data: 52224-89-2(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 1459-15-0 (R)-1-chloro-1-phenylethane 
• 108-95-2 phenol 
• 93-58-3 benzoic acid methyl ester 
• 100-42-5 styrene 
• 207573-11-3 (1R,3S,4S)-3-((S)-2-Methoxy-2-phenyl-ethylselanyl)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-one 
• 1517-69-7 (R)-1-phenylethanol 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 4809-56-7 N-(1-phenylethyl)-p-toluenesulfonamide 

Relevant articles and documents

Gold-catalyzed substitution reaction with ortho-alkynylbenzoic acid alkyl ester as an efficient alkylating agent

ortho-Alkynylbenzoic acid alkyl esters behave as alkylating agents in combination with gold catalysts. The reaction with alcohols occurs smoothly in the presence of catalytic amounts of Ph3PAuCl and AgOTf under mild conditions to produce the corresponding ether products in high yields. The protocol is also useful for Friedel-Crafts alkylation and N-alkylation of sulfonamides. The reaction likely proceeds through the gold-induced in situ construction of leaving groups and subsequent nucleophilic attack of nucleophiles, such as alcohols, aromatic compounds, and sulfonamides.

Novel polymer-bound chiral selenium electrophiles

(equation presented) Polymer-bound chiral electrophilic selenium reagents have been developed and applied to stereoselective selenenylation reactions of various alkenes. Different cleavage protocols allow further functionalization of the addition products

Asymmetric electrophilic methoxyselenenylations and cyclizations with 3- camphorseleno derivatives

A series of novel 3-camphor-based diselenides, differing in substitution at C-2, was prepared. The corresponding allyl selenides were used as protecting groups for the diselenide moieties in several subsequent transformations. The diastereoselective methoxyselenenylation of alkenes was achieved with methanolic selenenyl triflates derived from the camphor diselenides, of which the 2-keto analogue proved the most effective. Diastereoselective electrophilic cyclizations of unsaturated alcohols, carboxylic acids and amides were most effectively performed with the corresponding selenenyl chloride, containing a spiro-oxazolidinone moiety at C-2 of the camphor residue. The absolute configurations of several products were determined by reductive deselenization.