63471-86-3

Basic information

• Product Name: 4-[4-(4-chloro-benzoylamino)-phenyl]-4-oxo-butyric acid
• Synonyms: 4-[4-(4-chloro-benzoylamino)-phenyl]-4-oxo-butyric acid
• CAS NO: 63471-86-3
• Molecular Weight: 331.755
• Mol File: 63471-86-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-[4-(4-chloro-benzoylamino)-phenyl]-4-oxo-butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(4-chloro-benzoylamino)-phenyl]-4-oxo-butyric acid(63471-86-3)
• EPA Substance Registry System: 4-[4-(4-chloro-benzoylamino)-phenyl]-4-oxo-butyric acid(63471-86-3)

Safety Data

• Hazardous Substances Data: 63471-86-3(Hazardous Substances Data)

Upstream product

• 52240-85-4 4-(4-amino-phenyl)-4-oxo-butyric acid,methyl ester 
• 6945-94-4 4-(4-amino-phenyl)-4-oxo-butyric acid 
• 122-01-0 4-chloro-benzoyl chloride 
• 108-30-5 succinic acid anhydride 
• 6833-15-4 4-chlorobenzanilide 

Relevant articles and documents

Benzene butyric acids and their derivatives as inhibitors of matrix metalloproteinases

Benzene butyric acid compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and stromel

Fenbufen, a new anti inflammatory analgesic: synthesis and structure activity relationships of analogs

100 analogs of fenbufen were prepared and tested using the carrageenan, polyarthritis, and UV erythema anti inflammatory tests and the 2 phenyl 1,4 benzoquinone writhing and inflamed paw pressure analgesic tests. Only 3 retained the same full spectrum of activity as fenbufen: dl 4 (4 biphenylyl) 4 hydroxybutyric acid, dl 4 (4 biphenylyl) 1,4 butanediol, and 4 biphenylacetic acid. Fenbufen had the same spectrum of activity as aspirin, phenylbutazone, and indomethacin in the 5 tests. In addition, dose response derived potencies show fenbufen more potent than aspirin and at least as potent as phenylbutazone in all 5 tests. Two related compounds were generally similar.