52334-38-0

Usage

Uses

Used in Pharmaceutical Chemistry:
2-PHENYL-THIAZOLO[5,4-C]PYRIDINE is used as a building block for the synthesis of biologically active molecules due to its unique structure and reactivity, which contribute to the development of new pharmaceutical drugs.
Used in Medicinal Research:
2-PHENYL-THIAZOLO[5,4-C]PYRIDINE is used as a potential anti-cancer agent, with researchers investigating its efficacy in treating various types of cancer.
Used in Anti-Inflammatory Applications:
2-PHENYL-THIAZOLO[5,4-C]PYRIDINE is used as a potential anti-inflammatory agent, being studied for its ability to reduce inflammation and associated symptoms.
Used in Antimicrobial Applications:
2-PHENYL-THIAZOLO[5,4-C]PYRIDINE is used as a potential antimicrobial agent, being explored for its effectiveness against various microorganisms, including bacteria and fungi.
Used in Drug Development:
2-PHENYL-THIAZOLO[5,4-C]PYRIDINE is used as a versatile compound for further exploration and development in the field of pharmaceutical chemistry, with its potential applications spanning across different therapeutic areas.

Upstream product

• 936-61-8 Thiobenzoic acid O-ethyl ester 
• 19798-77-7 4-amino-3-chloropyridine 
• 65-85-0 benzoic acid 
• 116990-43-3 (4-amino-3-pyridyl) N,N-diisopropylcarbamodithioate 
• 1173707-06-6 C₁₂H₉IN₂O 
• 88511-27-7 3-iodopyridin-4-amine 
• 108-88-3 toluene 
• 1612227-97-0 N-(3-iodopyridin-4-yl)benzothioamide 
• 116608-23-2 N-(3-Chloro-pyridin-4-yl)-thiobenzamide 

Relevant academic research and scientific papers

A Convenient Procedure for the Formation of 2-Substituted Thiazolopyridines

2-Substituted thiazolo[4,5-b]pyridines and thiazolo[5,4-c]pyridines are prepared in reasonable yields by a procedure involving reaction of a mixture of ortho-amino (diisopropyldithiocarbamato) pyridine, carboxylic acid, and phosphorus oxychloride. The procedure provides a more convenient route than methods involving prior formation and isolation of the acid amide and cyclisation to give the desired product. The procedure is proven to be general for a wide range of substituents.

Copper-Catalyzed Benzylic C—H Functionalization, Oxidation and Cyclization of Methylarenes: Direct Access to 2-Arylbenzothiazoles

The direct C—H functionalization of methylarenes is of great significance. Herein, a copper-catalyzed oxidative C—N/C—S bond formation through benzylic C(sp3)—H functionalization, oxidation and cyclization of methylarenes is reported. Various 2-arylbenzothiazoles have been synthesized in moderate to excellent yields with readily available o-iodoaniline, potassium sulfide, and methylarenes as raw materials.

Room-temperature ligand-free Pd/C-catalyzed C-S bond formation: Synthesis of 2-substituted benzothiazoles

The synthesis of 2-substituted benzothiazoles has been achieved via cyclization of o-iodothiobenzanilide derivatives using Pd/C as the catalyst at room temperature. The protocol is ligand-free, additive-free, and high-yielding and involves very mild conditions.

Use of molecular oxygen as a reoxidant in the synthesis of 2-substituted benzothiazoles via palladium-catalyzed C-H functionalization/intramolecular C-S bond formation

Molecular oxygen (O2) was successfully employed as a reoxidant in cyclizations of thiobenzanilides 1a-s through a palladium-catalyzed C-H functionalization/intramolecular C-S bond formation process, leading to an efficient, green method for the synthesis of 2-arylbenzothiazoles 2a-s. Addition of cesium fluoride (CsF) greatly enhanced the reactions, which produced variously substituted 2-arylbenzothiazoles with good functional group tolerance. Thioureas 4a-j were also found to be suitable substrates for the cyclization process using a palladium/O2 catalyst system, thus generating 2-aminobenzothiazoles 5a-j. One-pot syntheses of 2-aminobenzothiazoles 5a-j from aryl isothiocyanates 6 and amines 7 were also successful.

Nouvelle methode de synthese de thiazolopyridines

It has been established that the direct condensation between aromatic and aliphatic thioesters and the variously generated anion of aminochloropyridines represents the best method for the synthesis of thiazolopyridines.The transient thioamides, sometimes isolated, can be easily converted chemically or photochemically into the desired fused heterocycles.