524-81-2 Usage
Uses
Used in Pharmaceutical Industry:
5-Benzyl-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole is used as a potential antipsychotic agent for the treatment of various mental disorders. Its unique molecular structure allows it to interact with specific receptors in the brain, helping to regulate neurotransmitter levels and alleviate symptoms associated with psychosis.
Used in Anxiolytic Applications:
In addition to its antipsychotic properties, 5-benzyl-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole is also being explored as an anxiolytic agent. It may help to reduce anxiety levels by modulating the activity of certain neurotransmitters, providing a potential therapeutic option for individuals suffering from anxiety disorders.
Used in Organic Synthesis:
5-Benzyl-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole is utilized in organic synthesis as a key intermediate in the production of various pharmaceuticals and other chemical compounds. Its unique structure allows for the formation of a wide range of derivatives, making it a valuable building block in the synthesis of new and innovative molecules.
Used in Medicinal Chemistry Research:
As a pyridine and indole derivative, 5-benzyl-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole is of interest to researchers in medicinal chemistry. Its potential pharmacological properties and unique molecular structure make it a promising candidate for further investigation and development as a therapeutic agent for various conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 524-81-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,2 and 4 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 524-81:
(5*5)+(4*2)+(3*4)+(2*8)+(1*1)=62
62 % 10 = 2
So 524-81-2 is a valid CAS Registry Number.
InChI:InChI=1/C19H20N2.C10H8O6S2/c1-20-12-11-19-17(14-20)16-9-5-6-10-18(16)21(19)13-15-7-3-2-4-8-15;11-17(12,13)9-5-1-3-7-8(9)4-2-6-10(7)18(14,15)16/h2-10H,11-14H2,1H3;1-6H,(H,11,12,13)(H,14,15,16)
524-81-2Relevant academic research and scientific papers
Preparation method of mebhydrolin napadisylate
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Paragraph 0023; 0028; 0029; 0030; 0035; 0036, (2019/06/30)
The invention belongs to the field of drug synthesis and provides a preparation method of mebhydrolin napadisylate. The preparation method is characterized by including the steps of firstly, subjecting methyl imine-N,N-methyl dipropionate and sodium methylate to heating under the effect of an organic solvent to achieve loop closing, and using hydrochloric acid to performing heating decarboxylationto obtain N-methyl-4-piperidone hydrochloride; subjecting phenylhydrazine and benzyl chloride to condensation under an alkaline condition to obtain benzyl phenylhydrazine; thirdly, mixing the N-methyl-4-piperidone hydrochloride solution and the benzyl phenylhydrazine, heating to generate mebhydrolin hydrochloride, adding disodium 1,5-naphthalenedisulfonate to obtain the mebhydrolin napadisylate.The preparation method is high in yield, mild in reaction conditions, convenient in intermediate purification and capable of satisfying the requirements of industrial production.
Indole cleavage with mebhydroline by sodium periodate: Part 1: Basic substituted indoles
Moehrle,Nestle,Westle
, p. 445 - 452 (2007/10/03)
The reaction behaviour of yohimbine (1), reserpine (5) and mebhydroline (7) as basic substituted indoles against periodate was examined. While 1 and 5 gave only the corresponding amine oxides 2 resp. 6 as definitive products, resulted from 7 beside the N-oxide 8 and stepwise dehydrogenation of the tetrahydro-γ-carboline to 9 and 13 also an attack at the indole system. In this ring contractions led to the spiro compounds 10 and 12 and with ring cleavage and loss of a C-1-unit the dilactam 11 was created.
