52578-66-2 Usage
Explanation
Different sources of media describe the Explanation of 52578-66-2 differently. You can refer to the following data:
1. The molecular formula represents the number of atoms of each element present in a molecule. In this case, the compound has 11 carbon (C) atoms, 12 hydrogen (H) atoms, 3 nitrogen (N) atoms, and 1 oxygen (O) atom.
2. This structure describes the arrangement of atoms and functional groups in the compound. It consists of a phenyl ring (C6H5) with an acetylamino group (-NHCOCH3) attached to the 4th position and a triaza-1,2-dien-2-ium group (C3H3N3+) attached to the 1st position.
3. Triaza-1,2-dien-2-ium derivative
3. The compound belongs to a class of chemical compounds called triaza-1,2-dien-2-ium derivatives, which are characterized by a triaza-1,2-dien-2-ium group (C3H3N3+) in their structure.
4. Phenyl ring
4. The compound contains a phenyl ring, which is a six-membered carbon ring with alternating single and double bonds and delocalized π electrons.
5. Acetylamino group
5. The compound has an acetylamino group (-NHCOCH3) attached to the phenyl ring. This functional group consists of an amine (-NH2) group with an acetyl group (-COCH3) attached to it.
6. Cationic nature
6. 1-[4-(acetylamino)phenyl]triaza-1,2-dien-2-ium is a cation, meaning it has a positive charge due to the presence of the triaza-1,2-dien-2-ium group (C3H3N3+).
7. Organic synthesis and medicinal chemistry
8. Potential antimicrobial and antifungal properties
7. Studies have shown that 1-[4-(acetylamino)phenyl]triaza-1,2-dien-2-ium has the potential to exhibit antimicrobial and antifungal properties, making it a candidate for further research in the development of new treatments for bacterial and fungal infections.
Chemical structure
1-[4-(acetylamino)phenyl]triaza-1,2-dien-2-ium
Check Digit Verification of cas no
The CAS Registry Mumber 52578-66-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,5,7 and 8 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 52578-66:
(7*5)+(6*2)+(5*5)+(4*7)+(3*8)+(2*6)+(1*6)=142
142 % 10 = 2
So 52578-66-2 is a valid CAS Registry Number.
52578-66-2Relevant articles and documents
Discovery of Cell-Permeable O-GlcNAc Transferase Inhibitors via Tethering in Situ Click Chemistry
Wang, Yue,Zhu, Jingjing,Zhang, Lianwen
, p. 263 - 272 (2017/04/26)
O-GlcNAc transferase (OGT) is a key enzyme involved in dynamic O-GlcNAcylation of nuclear and cytoplasmic proteins similar to phosphorylation. Discovery of cell-permeable OGT inhibitors is significant to clarify the function and regulatory mechanism of O-GlcNAcylation. This will establish the foundation for the development of therapeutic drugs for relevant diseases. Here, we report two cell-permeable OGT inhibitors (APNT and APBT), developed from low-activity precursors (IC50 > 1 mM) via “tethering in situ click chemistry (TISCC)”. Both of them were able to inhibit O-GlcNAcylation in cells without significant effects on cell viability. Unusual noncompetitive inhibition of OGT was helpful to discover novel inhibitors and explore the regulatory mechanism of OGT. The development of these molecules validates that TISCC can be utilized to discover novel lead compounds from components that exhibited very weak binding to the target.
One-pot synthesis of 1,4-disubstituted 1,2,3-triazoles from nitrobenzenes
Zhao, Fen,Chen, Zhen,Xie, Kai,Yang, Rui,Jiang, Yu-Bo
, p. 109 - 113 (2016/01/25)
A facile synthesis of 1,4-disubstituted 1,2,3-triazoles was achieved from nitrobenzenes and terminal alkynes under mild conditions. The reactions were successful for nitrobenzenes and terminal alkynes bearing various functionalities, from which the 1,2,3-triazole derivatives were smoothly synthesized through a four-step one-pot sequence.
Copper catalyzed synthesis of 1-aryl-1,2,3-triazoles from aryl iodides, alkynes, and sodium azide
Chen, Ying,Zhuo, Zi-Jian,Cui, Dong-Mei,Zhang, Chen
, p. 215 - 218 (2013/11/06)
Aryl azides were synthesized using heterogeneous porous Cu (0) catalyst via a coupling reaction of aryl iodides with sodium azide under mild conditions. Under the same conditions, one-pot Cu-catalyzed azide-alkyne cycloaddition of aryl iodides, alkynes, and sodium azide yielded 1-aryl-1,2,3-triazoles.
