52598-02-4

Basic information

• Product Name: 5-CHLORO-2,3-DIPHENYL-1H-INDOLE
• Synonyms: 5-CHLORO-2,3-DIPHENYL-1H-INDOLE
• CAS NO: 52598-02-4
• Molecular Formula: C₂₀H₁₄ClN
• Molecular Weight: 303.78
• Mol File: 52598-02-4.mol
• Article Data: 25

Chemical Properties

• Melting Point: 130-131 °C(Solv: ethanol (64-17-5))
• Boiling Point: 478.1 °C at 760 mmHg
• Flash Point: 275.1 °C
• Appearance: /
• Density: 1.243 g/cm³
• Vapor Pressure: 7.63E-09mmHg at 25°C
• Refractive Index: 1.682
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 15.63±0.30(Predicted)
• CAS DataBase Reference: 5-CHLORO-2,3-DIPHENYL-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2,3-DIPHENYL-1H-INDOLE(52598-02-4)
• EPA Substance Registry System: 5-CHLORO-2,3-DIPHENYL-1H-INDOLE(52598-02-4)

Safety Data

• Hazardous Substances Data: 52598-02-4(Hazardous Substances Data)

Usage

General Description

5-Chloro-2,3-diphenyl-1H-indole is a synthetic organic compound that belongs to the class of chemicals known as diphenylindoles. Its molecular formula is C20H14ClN and it has a molar mass of 307.785 g·mol?1. This chemical possesses an aromatic structure with chlorine substitution at the 5th position of the indole ring. The two phenyl groups are attached to the 2nd and 3rd positions of the indole. Despite being less researched compared to other indole derivatives, it possesses potential to contribute towards fields such as material science due to its optical properties, pharmaceuticals because of potential biological activity, and organic chemistry for synthesis studies.

InChI:InChI=1/C20H14ClN/c21-16-11-12-18-17(13-16)19(14-7-3-1-4-8-14)20(22-18)15-9-5-2-6-10-15/h1-13,22H

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Downstream Products

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Relevant articles and documents

Synthesis of Unprotected and Highly Substituted Indoles by the Ruthenium(II)-Catalyzed Reaction of Phenyl Isocyanates with Diaryl/Diheteroaryl Alkynes/Ethyl-3-phenyl Propiolates

A one-pot transformation has been developed for the synthesis of unprotected and highly substituted indoles by an in situ installed carbamide-directed Ru(II)-catalyzed intermolecular oxidative annulation of phenyl isocyanates with diaryl/diheteroaryl alkynes/ethyl phenyl propiolates in the presence of Cu(OAc)2·H2O as an oxidant and AgSbF6 as an additive at 120 °C within 3 h.

Method for preparing indole compounds by using rhodium/carbon as catalyst

The invention provides a method for preparing indole compounds by using rhodium/carbon as a catalyst. Corresponding indole compounds are formed through subjecting aniline and analogs thereof and alkyne to a catalytic cyclization reaction in the presence of the rhodium/carbon. The method has the beneficial effects that the preparation method is simple in process, the raw materials are cheap and readily available, the yield is high, inert-gas protection is not required, and the reaction temperature is relatively moderate.

Transition-metal-free, visible-light-mediated cyclization of: O -azidoarylalkynes with aryl diazonium salts

Visible light along with 3 mol% eosin Y catalyzes the cyclization reaction of o-azidoarylalkynes with aryl diazonium salts by a photoredox process. We have investigated the scope of the reaction for several aryl diazonium salts and o-azidoarylalkynes. The general and easy procedure provides a transition-metal-free alternative for the formation of unsymmetrical 2,3-diaryl-substitued indoles.