526-21-6

Usage

Uses

Used in Pharmaceutical Industry:
Glycine,N-(2-aminobenzoyl)is used as a building block for the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and chemical products.
Used in Organic Synthesis:
Glycine,N-(2-aminobenzoyl)is used as a reagent in organic synthesis, facilitating the creation of complex organic compounds and contributing to advancements in chemical research.
Used in Peptide-based Drug Production:
Glycine,N-(2-aminobenzoyl)is used as a precursor in the production of peptide-based drugs, playing a crucial role in the development of innovative therapeutic agents.
Used in Neurological Disorder Treatment Research:
Glycine,N-(2-aminobenzoyl)has been studied for its potential role in the treatment of neurological disorders, offering a promising avenue for the development of new therapies and interventions.
Used in Material and Bioconjugate Development:
Glycine,N-(2-aminobenzoyl)is used as a building block for the development of new materials and bioconjugates, expanding its applications in various scientific and industrial fields.

InChI:InChI=1/C9H10N2O3/c10-7-4-2-1-3-6(7)9(14)11-5-8(12)13/h1-4H,5,10H2,(H,11,14)(H,12,13)

Upstream product

• 10167-23-4 N-(2-nitrobenzoyl)glycine 
• 118-48-9 isatoic anhydride 
• 5177-49-1 ethyl 2-(2-nitrobenzamido)acetate 
• 118-92-3 anthranilic acid 
• 610-14-0 2-nitrobenzyl chloride 
• 552-16-9 ortho-nitrobenzoic acid 
• 63254-88-6 2-{[(benzyloxy)carbonyl]amino}benzoic acid 
• 866431-50-7 methyl [(2-{[(benzyloxy)carbonyl]amino}benzoyl)amino]acetate 
• 150374-96-2 N-(2-nitrobenzoyl)glycine benzyl ester 
• 56-40-6 glycine 
• 21563-73-5 2-aminobenzoyl chloride 
• 67482-93-3 o-aminobenzoylglycyl-p-nitro-L-phenylalanyl-L-proline 
• 5973-34-2 (2-aminobenzoylamino)acetic acid ethyl ester 

Downstream Products

• 127373-66-4 N-[o-(p-pivaloyloxybenzenesulfonylamino)benzoyl]glycine 
• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 
• 14663-53-7 3-carboxymethyl-3,4-dihydro-4(1H)-quinazolinone 
• 866431-51-8 2-amino-N-{2-[(1-{[(methyl)(phenyl)amino]carbonyl}cyclopentyl)amino]-2-oxoethyl}benzamide 
• 97609-01-3 2-(4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)acetic acid 
• 67482-93-3 o-aminobenzoylglycyl-p-nitro-L-phenylalanyl-L-proline 
• 105217-20-7 2-Ureido-hippursaeure 
• 58352-46-8 N-(N-acetyl-anthraniloyl)-glycine 

Relevant academic research and scientific papers

TARGETED DELIVERY TO BETA CELLS

The disclosure includes zinc prodrugs for targeted delivery of therapeutic, diagnostic or imaging agents to β-cells and methods of use therefor. The disclosure also includes targeted delivery of small molecules to β-cells that stabilize and activate CRISP

Efficient synthesis of sivelestat sodium hydrate

An efficient and scaleable synthesis of sivelestat sodium hydrate has been developed. Copyright Taylor & Francis Group, LLC.

Application of the 'direct amide cyclization' to peptides containing an anthranilic acid residue

The 2,2-disubstituted 2H-azirin-3-amines 7a-7c were used as amino acid synthons to prepare linear peptides derived from anthranilic acid. These linear peptides, which contain α,α-disubstituted α-amino acids, were synthesized by using the 'azirine/oxazolon

Neutral, acidic, and basic derivatives of anthranilamide that confer different formal charge to reducing oligosaccharides

To facilitate the use of oligosaccharides as analytical tools in biological studies, we have designed, synthesized, and conjugated to maltosaccharides a novel series of homologous small fluorescent moieties that differ in formal charge. These moieties are

Synthesis and in Vitro Aldolase Reductase Inhibitory Activity of Compounds Containing an N-Acylglycine Moiety

A number of N-benzoylglycines (6), N-acetyl-N-phenylglycines (7), N-benzoyl-N-phenylglycines (8), and tricyclic N-acetic acids (9-12) were synthesized as analogues of the N-acylglycine-containing aldolase reductase inhibitors alrestatin and 2-oxoquinoline-1-acetic acid.Derivatives of 6, which represent ring-simplified analogues of alrestatin, are very weak inhibitors of aldolase reductase obtained from rat lens, producing 50percent inhibition only at concentrations exceeding 100 μM.Compounds of series 7 were designed as ring-opened analogues of the 2-oxoquinolines.While this derivatives are more potent than compounds of series 6 (IC 50s of 6-80 μM), they are less active than the corresponding 2-oxoquinolines.Analogues of series 8 were designed as hybrid structures of both alrestatin and the 2-oxoquinoline-1-acetic acids.These compounds are substantially more potent than compounds of series 6 and 7 and display inhibitory activities comparable to or greater than alrestatin or the 2-oxoquinolines (IC 50s of 0.1-10 μM).Of the rigid analogues of 8, the most potent derivative is benzoxindol (12) with an IC 50 of 0.67 μM, suggesting that fusion of the two aromatic rings of 8 in a coplanar conformation may optimize affinity for aldose reductase in this series.